Cisplatin (CP) is an anticancer medication that is commonly used to treat solid tumors. Its
use is, however, dose-restricted due to nephrotoxicity. We planned to compare the …

Regarding the mechanisms of cisplatin (CP) nephrotoxicity, several hypotheses have been
put forward, among which oxidative stress (including depletion of glutathione and production …

Cisplatin (CP) is a potent anticancer drug used to treat solid tumors. Its use, however, is
dose-limited by its nephrotoxicity. We aimed to compare the effect of melatonin and …

Background Cisplatin, one of the most effective and potent anticancer drugs, is used in the
treatment of a wide variety of both pediatric and adult malignancies. However, the …

The present study focused on the protective effects of melatonin against cisplatin-induced
acute kidney injury in mice and its possible mechanism of action in relation to the major …

Cisplatin is used to treat various types of cancers. Its use is limited, however, due to nephro-
toxicity, which may result from free radical damage. Evidence exists that melatonin reduces …

Despite the enormous advances made in the field of oncology, no solution to the side effect
of nephrotoxicity caused by cisplatin used as an antineoplastic agent for approximately 40 …

Introduction Cisplatin-induced nephrotoxicity (CIN) is a major dose-limiting factor in cisplatin
use for the management of human cancers. This study was designed to evaluate the effect of …

Cisplatin-induced acute renal injury is the most common and serious side effect, sometimes
requiring discontinuation of the treatment. Thus, the development of new protective …

Nephrotoxicity is a dose-dependent side effect of cisplatin and γ-radiation that limits their
clinical usage in the field of cancer treatments. The present study was designed to evaluate …