Characterization of purine‐rich element binding protein B as a novel biomarker in acute myelogenous leukemia prognostication
RJ Kelm Jr, GS Lamba, JE Levis… - Journal of cellular …, 2018 - Wiley Online Library
Acute myelogenous leukemia (AML) is an aggressive hematologic cancer characterized by
infiltration of proliferative, clonal, abnormally differentiated cells of myeloid lineage in the …
infiltration of proliferative, clonal, abnormally differentiated cells of myeloid lineage in the …
[HTML][HTML] The significance of low PU. 1 expression in patients with acute promyelocytic leukemia
Background Although the importance of the hematopoietic transcription factor PU. 1 in acute
myeloid leukemia (AML) has been demonstrated, the expression of PU. 1 in acute …
myeloid leukemia (AML) has been demonstrated, the expression of PU. 1 in acute …
PU. 1 is essential for MLL leukemia partially via crosstalk with the MEIS/HOX pathway
J Zhou, J Wu, B Li, D Liu, J Yu, X Yan, S Zheng, J Wang… - Leukemia, 2014 - nature.com
Mixed lineage leukemia (MLL) fusion proteins directly activate the expression of key
downstream genes such as MEIS1, HOXA9 to drive an aggressive form of human leukemia …
downstream genes such as MEIS1, HOXA9 to drive an aggressive form of human leukemia …
[HTML][HTML] Structurally differentiated cis-elements that interact with PU.1 are functionally distinguishable in acute promyelocytic leukemia
Background Transcription factor PU. 1, a member of the ETS family, is a master regulator of
myeloid differentiation whose functional disruption is often associated with acute myeloid …
myeloid differentiation whose functional disruption is often associated with acute myeloid …
Correlation of PU. 1 and signal regulatory protein α1 expression in PU. 1 transgenic K562 cells
Y Iseki, M Nakahara, M Kubo… - International …, 2012 - spandidos-publications.com
PU. 1 is a key transcription factor for hematopoiesis and the reduction of this protein
expression plays important roles in various hematological malignancies. To identify PU. 1 …
expression plays important roles in various hematological malignancies. To identify PU. 1 …
PU. 1 and CEBPA expression in acute myeloid leukemia
F D'Alò, A Di Ruscio, F Guidi, E Fabiani, M Greco… - Leukemia research, 2008 - Elsevier
Alterations of the transcription factors CCAAT/enhancer binding protein alpha (CEBPA) and
PU. 1 have been described in acute myeloid leukemia (AML). We studied CEBPA and PU. 1 …
PU. 1 have been described in acute myeloid leukemia (AML). We studied CEBPA and PU. 1 …
Protein expression and constitutive phosphorylation of hematopoietic transcription factors PU. 1 and C/EBP beta in acute myeloid leukemia blasts.
H Iida, M Towatari, M Iida, M Tanimoto… - … journal of hematology, 2000 - europepmc.org
The transcriptional activity of transcription factors is regulated by phosphorylation. The
uncontrolled expression and constitutive activation of transcriptional regulators have been …
uncontrolled expression and constitutive activation of transcriptional regulators have been …
[HTML][HTML] Expression profiling of some Acute Myeloid Leukemia-associated markers to assess their diagnostic/prognostic potential
Investigating the etiological causes of acute myeloid leukemia (AML) at the molecular level
should help in identifying targets and strategies that would increase the efficacy of the …
should help in identifying targets and strategies that would increase the efficacy of the …
The importance of PU. 1 concentration in hematopoietic lineage commitment and maturation
PU. 1 is an Ets family transcription factor that is required for the development of myeloid and
lymphoid cells. Since PU. 1 is required for several different lineages it has been unclear …
lymphoid cells. Since PU. 1 is required for several different lineages it has been unclear …
[HTML][HTML] PU. 1 and Junb: suppressing the formation of acute myeloid leukemia stem cells
TCP Somervaille, ML Cleary - Cancer cell, 2006 - cell.com
Improved understanding of the molecular pathways that suppress the genesis and
maintenance of cancer stem cells will facilitate development of rationally targeted therapies …
maintenance of cancer stem cells will facilitate development of rationally targeted therapies …