Type 1 diabetes (T1D) is a chronic autoimmune disease that causes severe loss of
pancreatic β cells. Autoreactive T cells are key mediators of β cell destruction. Studies of …

Type 1 diabetes mellitus results from a T-cell mediated autoimmune destruction of the
pancreatic beta cells in genetically predisposed individuals. The knowledge of the …

The mechanisms underlying type 1 diabetes (T1D) pathogenesis remain largely unknown.
While autoantibodies to pancreatic beta-cell antigens are often the first biological response …

According to the quality of response they mediate, autoreactive T cells recognizing islet β
cell peptides could represent both disease effectors in the development of type 1 diabetes …

Abstract Type 1 diabetes (T1D), an autoimmune disease once thought to be mediated
exclusively by β cell-specific CD4+ T cells, is now recognized as one in which autoreactive …

Type 1 diabetes (T1D) is an autoimmune disease driven by the activation of lymphocytes
against pancreatic β‐cells. Among β‐cell autoantigens, preproinsulin has been ascribed a …

Type 1 diabetes (T1D) is an autoimmune disease that occurs in genetically susceptible
individuals. Regulatory T cells (Tregs) have been shown to be defective in the autoimmune …

Regulatory T cells (Tregs) control organ-specific autoimmunity in a tissue antigen-specific
manner, yet little is known about their specificity in a natural repertoire. In this study, we used …

Type 1 diabetes (T1D) results from destruction of pancreatic beta cells by T cells of the
immune system. Despite improvements in insulin analogs and continuous blood glucose …

The adaptive immune repertoire plays a critical role in type 1 diabetes (T1D) pathogenesis.
However, efforts to characterize B cell and T cell receptor (TCR) profiles in T1D subjects …