Methicillin-resistant Staphylococcus aureus (MRSA) is a frequent cause of difficult-to-treat,
often fatal infections in humans,. Most humans have antibodies against S. aureus, but these …

Most clonal lineages of Staphylococcus epidermidis are commensals present on human
skin and in the nose. However, some globally spreading healthcare-associated and …

The cell wall of Gram-positive bacteria is a complex network of surface proteins, capsular
polysaccharides and wall teichoic acids (WTA) covalently linked to Peptidoglycan (PG). The …

Staphylococcus epidermidis expresses glycerol phosphate wall teichoic acid (WTA), but
some health care–associated methicillin-resistant S. epidermidis (HA-MRSE) clones …

Staphylococcus aureus is considered to be an extracellular pathogen. However, survival of
S. aureus within host cells may provide a reservoir relatively protected from antibiotics, thus …

Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) are the
cause of a severe pandemic consisting primarily of skin and soft tissue infections. The …

Staphylococcus aureus peptidoglycan (PG) is densely functionalized with anionic polymers
called wall teichoic acids (WTAs). These polymers contain three tailoring modifications: d …

Daptomycin is a bactericidal antibiotic of last resort for serious infections caused by
methicillin-resistant Staphylococcus aureus (MRSA) 1, 2. Although resistance is rare …

Addressing the ongoing antibiotic crisis requires the discovery of compounds with novel
mechanisms of action that are capable of treating drug-resistant infections. Many antibiotics …

Staphylococcus aureus small colony variants (SCVs) are frequently associated with chronic
infection, yet they lack expression of many virulence determinants associated with the …