Methicillin-resistant Staphylococcus aureus alters cell wall glycosylation to evade immunity
D Gerlach, Y Guo, C De Castro, SH Kim, K Schlatterer… - Nature, 2018 - nature.com
Methicillin-resistant Staphylococcus aureus (MRSA) is a frequent cause of difficult-to-treat,
often fatal infections in humans,. Most humans have antibodies against S. aureus, but these …
often fatal infections in humans,. Most humans have antibodies against S. aureus, but these …
Staphylococcus epidermidis clones express Staphylococcus aureus-type wall teichoic acid to shift from a commensal to pathogen lifestyle
Most clonal lineages of Staphylococcus epidermidis are commensals present on human
skin and in the nose. However, some globally spreading healthcare-associated and …
skin and in the nose. However, some globally spreading healthcare-associated and …
Wall Teichoic Acids of Staphylococcus aureus Limit Recognition by the Drosophila Peptidoglycan Recognition Protein-SA to Promote Pathogenicity
The cell wall of Gram-positive bacteria is a complex network of surface proteins, capsular
polysaccharides and wall teichoic acids (WTA) covalently linked to Peptidoglycan (PG). The …
polysaccharides and wall teichoic acids (WTA) covalently linked to Peptidoglycan (PG). The …
Invasive Staphylococcus epidermidis uses a unique processive wall teichoic acid glycosyltransferase to evade immune recognition
Staphylococcus epidermidis expresses glycerol phosphate wall teichoic acid (WTA), but
some health care–associated methicillin-resistant S. epidermidis (HA-MRSE) clones …
some health care–associated methicillin-resistant S. epidermidis (HA-MRSE) clones …
Novel antibody–antibiotic conjugate eliminates intracellular S. aureus
SM Lehar, T Pillow, M Xu, L Staben, KK Kajihara… - Nature, 2015 - nature.com
Staphylococcus aureus is considered to be an extracellular pathogen. However, survival of
S. aureus within host cells may provide a reservoir relatively protected from antibiotics, thus …
S. aureus within host cells may provide a reservoir relatively protected from antibiotics, thus …
Wall teichoic acids mediate increased virulence in Staphylococcus aureus
S Wanner, J Schade, D Keinhörster, N Weller… - Nature …, 2017 - nature.com
Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) are the
cause of a severe pandemic consisting primarily of skin and soft tissue infections. The …
cause of a severe pandemic consisting primarily of skin and soft tissue infections. The …
Methicillin resistance in Staphylococcus aureus requires glycosylated wall teichoic acids
S Brown, G Xia, LG Luhachack… - Proceedings of the …, 2012 - National Acad Sciences
Staphylococcus aureus peptidoglycan (PG) is densely functionalized with anionic polymers
called wall teichoic acids (WTAs). These polymers contain three tailoring modifications: d …
called wall teichoic acids (WTAs). These polymers contain three tailoring modifications: d …
Staphylococcus aureus inactivates daptomycin by releasing membrane phospholipids
V Pader, S Hakim, KL Painter, S Wigneshweraraj… - Nature …, 2016 - nature.com
Daptomycin is a bactericidal antibiotic of last resort for serious infections caused by
methicillin-resistant Staphylococcus aureus (MRSA) 1, 2. Although resistance is rare …
methicillin-resistant Staphylococcus aureus (MRSA) 1, 2. Although resistance is rare …
Evolution-guided discovery of antibiotics that inhibit peptidoglycan remodelling
Addressing the ongoing antibiotic crisis requires the discovery of compounds with novel
mechanisms of action that are capable of treating drug-resistant infections. Many antibiotics …
mechanisms of action that are capable of treating drug-resistant infections. Many antibiotics …
Staphylococcus aureus small colony variants impair host immunity by activating host cell glycolysis and inducing necroptosis
Staphylococcus aureus small colony variants (SCVs) are frequently associated with chronic
infection, yet they lack expression of many virulence determinants associated with the …
infection, yet they lack expression of many virulence determinants associated with the …