Radiation-induced endothelial/vascular injury is a major complicating factor in radiotherapy
and a leading cause of morbidity and mortality in nuclear or radiological catastrophes …

In radiation therapy for cancer, the therapeutic ratio represents an optimal balance between
tumor control and normal tissue complications. As improvements in the therapeutic arsenal …

Most cancer patients are treated with radiotherapy, but the treatment can also damage the
surrounding normal tissue. Radiotherapy side-effects diminish patients' quality of life, yet …

The association between late damage in irradiated tissues and the vasculature was reported
shortly after the discovery of X-rays. Gross blood vessel abnormalities were a consistent …

The endothelium, a tissue that forms a single layer of cells lining various organs and cavities
of the body, especially the heart and blood as well as lymphatic vessels, plays a complex …

Altered by ionising radiation, the vascular network is considered as a prime target to limit
normal tissue damage and improve tumour control in radiotherapy (RT). Irradiation damages …

Publisher Summary This chapter discusses radiation-induced vascular injury and its relation
to late effects in normal tissues. It presents a summarization of the threshold doses and times …

To summarize current knowledge regarding mechanisms of radiation-induced normal tissue
injury and medical countermeasures available to reduce its severity. Advances in radiation …

Purpose: The use of clinical radiation for cancer treatment is limited by damage to
underlying normal tissue including to the vascular endothelium. We investigated the …

PURPOSE: To investigate the effects of radiation on the endothelial cytoskeleton and
endothelial monolayer permeability and to evaluate associated signaling pathways, which …