Activated astrocytes are a primary source of inflammatory factors following traumatic optic
neuropathy (TON). Accumulation of inflammatory factors in this context leads to increased …

Purpose To investigate the potential protective effect of novel G protein coupled estrogen
receptor (GPER1) against the neurotoxicity induced by NMDA in the mouse retina. Methods …

Background Early brain injury (EBI) caused by inflammatory responses in acute phase of
Intracerebral hemorrhage (ICH) plays a vital role in the pathological progression of ICH …

Background. Traumatic optic neuropathy (TON) refers to damage to the optic nerve resulting
from direct and indirect trauma to the head and face. One of the important pathological …

Chronic neuro-inflammation is involved in the death of retinal ganglion cells (RGCs) in
glaucoma. The aim of this study is to determine whether wogonin can suppress inflammatory …

Traumatic optic neuropathy (TON) refers to a pathological condition caused by a direct or
indirect insult to the optic nerves, which often leads to a partial or permanent vision deficit …

Optic neuropathies are leading causes of irreversible visual impairment and blindness,
currently affecting more than 100 million people worldwide. Glaucoma is a group of optic …

The purpose of this study was to investigate the effects of epigallocatechin-3-gallate (EGCG)
in axotomized eyes and the pathways related to its action. Wistar rats received intracranial …

Acute glaucoma is a vision-threatening disease characterized by a sudden elevation in
intraocular pressure (IOP), followed by retinal ganglion cell (RGC) death. Cytosolic double …

Background Retinal ganglion cell (RGC) soma death is a consequence of optic nerve
damage, including in optic neuropathies like glaucoma. The activation of the innate immune …