There is a large body of literature demonstrating the efficacy of maternal folic acid intake in
preventing birth defects, as well as investigations into potential adverse consequences of …

Based on animal studies, epidemiologic studies and intervention trials, maternal folic acid is
known to be protective for neural tube defects (NTD), primarily spina bifida and …

An adequate intake of folate during pregnancy, lactation, and infancy is essential for
maternal and child health and normal growth. Higher folate requirements during pregnancy …

ABSTRACT The Government of Canada and the Society of Obstetricians and
Gynaecologists of Canada both recommend a daily multivitamin supplement containing 400 …

Periconceptual folic acid prevents neural tube defects. The effect of folic acid taken
throughout pregnancy is unclear, however. We re‐analysed data from a large randomised …

Folate is a water-soluble B vitamin that must be obtained in the diet or through
supplementation. For> 50 yr, it has been known that folate plays an integral role in …

Periconceptional intake of folic acid is known to reduce a woman's risk of having an infant
affected by a neural tube birth defect (NTD). National programs to mandate fortification of …

Objective To provide updated guidance on pre-conception folic acid and multivitamin
supplementation for primary and secondary (recurrence) prevention of neural tube defects …

Thirty years ago, it was suggested that maternal intake of certain vitamins during pregnancy
affected the incidence of serious fetal malformations. Subsequent research has revealed …

The association between folic acid supplementation, prior to conception and/or during
pregnancy and pregnancy outcomes, has been the subject of numerous studies. The …