Ceftriaxone alters the gut microbiome composition and reduces alcohol intake in male and female Sprague-Dawley rats
F Duclot, L Wu, CS Wilkinson, M Kabbaj, LA Knackstedt - Alcohol, 2024 - Elsevier
Ceftriaxone is an antibiotic that increases central nervous system (CNS) protein expression
of the glutamate transporters GLT-1 and xCT and ameliorates pathological behaviors in …
of the glutamate transporters GLT-1 and xCT and ameliorates pathological behaviors in …
Molecular changes evoked by the beta-lactam antibiotic ceftriaxone across rodent models of substance use disorder and neurological disease
I Smaga, D Fierro, J Mesa, M Filip… - … & Biobehavioral Reviews, 2020 - Elsevier
Ceftriaxone is a beta-lactam antibiotic that increases the expression of the major glutamate
transporter, GLT-1. As such, ceftriaxone ameliorates symptoms across multiple rodent …
transporter, GLT-1. As such, ceftriaxone ameliorates symptoms across multiple rodent …
Alcohol-induced changes in the gut microbiome and metabolome of rhesus macaques
X Zhang, K Yasuda, RA Gilmore, SV Westmoreland… - …, 2019 - Springer
Rationale Increasing evidence has demonstrated that changes in the gut microbiome,
including those associated with dietary influences, are associated with alterations in many …
including those associated with dietary influences, are associated with alterations in many …
Effects of ceftriaxone on chronic ethanol consumption: a potential role for xCT and GLT1 modulation of glutamate levels in male P rats
Alterations in glutamatergic neurotransmission have been suggested to affect many aspects
of neuroplasticity associated with alcohol/drug addiction. We have previously shown that …
of neuroplasticity associated with alcohol/drug addiction. We have previously shown that …
Ceftriaxone reduces alcohol intake in outbred rats while upregulating xCT in the nucleus accumbens core
Alcohol addiction is a chronic disease characterized by an inability to regulate drinking. A
critical brain region involved in alcohol consumption is the nucleus accumbens (NA) …
critical brain region involved in alcohol consumption is the nucleus accumbens (NA) …
Antibiotic-induced disruption of commensal microbiome linked to increases in binge-like ethanol consumption behavior
REN Reyes, AJ Al Omran, DL Davies, L Asatryan - Brain research, 2020 - Elsevier
Research focusing on the gut-brain axis is growing, but the interplay of ethanol (alcohol
molecule), the gut microbiome, the brain and behavior is poorly understood. In the current …
molecule), the gut microbiome, the brain and behavior is poorly understood. In the current …
Effects of moderate, voluntary ethanol consumption on the rat and human gut microbiome
KL Kosnicki, JC Penprase, P Cintora… - Addiction …, 2019 - Wiley Online Library
Many alcohol‐induced health complications are directly attributable to the toxicity of alcohol
or its metabolites, but another potential health impact of alcohol may be on the microbial …
or its metabolites, but another potential health impact of alcohol may be on the microbial …
Ceftriaxone, a beta-lactam antibiotic, reduces ethanol consumption in alcohol-preferring rats
Y Sari, M Sakai, JM Weedman, GV Rebec… - Alcohol and …, 2011 - academic.oup.com
Aims: Changes in glutamatergic transmission affect many aspects of neuroplasticity
associated with ethanol and drug addiction. For instance, ethanol-and drug-seeking …
associated with ethanol and drug addiction. For instance, ethanol-and drug-seeking …
The gut microbiome and alcoholic liver disease: ethanol consumption drives consistent and reproducible alteration in gut microbiota in mice
Phenotypic health effects, both positive and negative, have been well studied in association
with the consumption of alcohol in humans as well as several other mammals including …
with the consumption of alcohol in humans as well as several other mammals including …
Gut microbiome and metabolome in a non-human primate model of chronic excessive alcohol drinking
D Piacentino, S Grant-Beurmann, C Vizioli, X Li… - Translational …, 2021 - nature.com
A relationship between the gut microbiome and alcohol use disorder has been suggested.
Excessive alcohol use produces changes in the fecal microbiome and metabolome in both …
Excessive alcohol use produces changes in the fecal microbiome and metabolome in both …