Ceftriaxone alters the gut microbiome composition and reduces alcohol intake in male and female Sprague-Dawley rats

F Duclot, L Wu, CS Wilkinson, M Kabbaj, LA Knackstedt - Alcohol, 2024 - Elsevier
Ceftriaxone is an antibiotic that increases central nervous system (CNS) protein expression
of the glutamate transporters GLT-1 and xCT and ameliorates pathological behaviors in …

Molecular changes evoked by the beta-lactam antibiotic ceftriaxone across rodent models of substance use disorder and neurological disease

I Smaga, D Fierro, J Mesa, M Filip… - … & Biobehavioral Reviews, 2020 - Elsevier
Ceftriaxone is a beta-lactam antibiotic that increases the expression of the major glutamate
transporter, GLT-1. As such, ceftriaxone ameliorates symptoms across multiple rodent …

Alcohol-induced changes in the gut microbiome and metabolome of rhesus macaques

X Zhang, K Yasuda, RA Gilmore, SV Westmoreland… - …, 2019 - Springer
Rationale Increasing evidence has demonstrated that changes in the gut microbiome,
including those associated with dietary influences, are associated with alterations in many …

Effects of ceftriaxone on chronic ethanol consumption: a potential role for xCT and GLT1 modulation of glutamate levels in male P rats

PSS Rao, Y Sari - Journal of Molecular Neuroscience, 2014 - Springer
Alterations in glutamatergic neurotransmission have been suggested to affect many aspects
of neuroplasticity associated with alcohol/drug addiction. We have previously shown that …

Ceftriaxone reduces alcohol intake in outbred rats while upregulating xCT in the nucleus accumbens core

BA Stennett, JC Frankowski, J Peris… - Pharmacology …, 2017 - Elsevier
Alcohol addiction is a chronic disease characterized by an inability to regulate drinking. A
critical brain region involved in alcohol consumption is the nucleus accumbens (NA) …

Antibiotic-induced disruption of commensal microbiome linked to increases in binge-like ethanol consumption behavior

REN Reyes, AJ Al Omran, DL Davies, L Asatryan - Brain research, 2020 - Elsevier
Research focusing on the gut-brain axis is growing, but the interplay of ethanol (alcohol
molecule), the gut microbiome, the brain and behavior is poorly understood. In the current …

Effects of moderate, voluntary ethanol consumption on the rat and human gut microbiome

KL Kosnicki, JC Penprase, P Cintora… - Addiction …, 2019 - Wiley Online Library
Many alcohol‐induced health complications are directly attributable to the toxicity of alcohol
or its metabolites, but another potential health impact of alcohol may be on the microbial …

Ceftriaxone, a beta-lactam antibiotic, reduces ethanol consumption in alcohol-preferring rats

Y Sari, M Sakai, JM Weedman, GV Rebec… - Alcohol and …, 2011 - academic.oup.com
Aims: Changes in glutamatergic transmission affect many aspects of neuroplasticity
associated with ethanol and drug addiction. For instance, ethanol-and drug-seeking …

The gut microbiome and alcoholic liver disease: ethanol consumption drives consistent and reproducible alteration in gut microbiota in mice

ES LeBrun, M Nighot, V Dharmaprakash, A Kumar… - Life, 2020 - mdpi.com
Phenotypic health effects, both positive and negative, have been well studied in association
with the consumption of alcohol in humans as well as several other mammals including …

Gut microbiome and metabolome in a non-human primate model of chronic excessive alcohol drinking

D Piacentino, S Grant-Beurmann, C Vizioli, X Li… - Translational …, 2021 - nature.com
A relationship between the gut microbiome and alcohol use disorder has been suggested.
Excessive alcohol use produces changes in the fecal microbiome and metabolome in both …