The aim of the research was to develop novel gallic acid (GA)-modified amphiphilic
nanoparticles of polyethylenimine (PEI)–polypropylene carbonate (PPC)–PEI (PEPE) and …

Purpose: In order to overcome the problem that conventional pharmacological treatments of
periodontitis cannot effectively synergizing antimicrobial and immunomodulation, inspired …

Chronic periodontitis is one of the most common oral diseases worldwide and the excessive
local reactive oxygen species (ROS) level of periodontitis aggravates the destruction of …

Periodontitis is an inflammatory disease, mainly caused by the formation of a subgingival
plaque biofilm. In recent years, growing attention has been paid to immunotherapy in the …

Nanodrug delivery systems (NDDSs) for the treatment of periodontitis remain a significant
clinical challenge. The low biocompatibility, singular effect, and lack of disease specificity of …

Periodontitis is a chronic inflammatory disease caused by the interaction of oral
microorganisms with the host immune response. Porphyromonas gingivalis (Pg) acts as a …

Purpose: In a previous study, we found that oligodeoxynucleotide (ODN) YW002 could
induce the activity of alkaline phosphatase of early osteogenesis in human periodontal …

Long term retention of antimicrobials with effective drug concentration in gingival crevicular
fluid (GCF) is of vital importance for the treatment of chronic periodontitis. In this study, a …

Chronic periodontitis is a chronic, progressive, and destructive disease. Especially, the large
accumulation of advanced glycation end products (AGEs) in a diseased body will aggravate …

Background Rapid local drug clearance of antimicrobials is a major drawback for the
treatment of chronic periodontitis. In the study reported here, minocycline-loaded poly …