The role of PfEMP1 as targets of naturally acquired immunity to childhood malaria: prospects for a vaccine

PC Bull, AI Abdi - Parasitology, 2016 - cambridge.org
The Plasmodium falciparum erythrocyte membrane protein 1 antigens that are inserted onto
the surface of P. falciparum infected erythrocytes play a key role both in the pathology of …

Seroreactivity to Plasmodium falciparum Erythrocyte Membrane Protein 1 Intracellular Domain in Malaria-Exposed Children and Adults

MA Travassos, A Niangaly, JA Bailey… - The Journal of …, 2013 - academic.oup.com
Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) antigens mediate
parasite sequestration and host immune evasion. Reactivity to 21 PfEMP1 fragments on a …

PfEMP1 as a target of human immunity and a vaccine candidate against malaria

JG Beeson, JA Chan, FJI Fowkes - Expert review of vaccines, 2013 - Taylor & Francis
Editorial studies have shown that antibodies are acquired naturally to multiple different
domains of PfEMP1 after repeated exposure to infection, but associations with protective …

Plasmodium falciparum var gene expression is modified by host immunity

GM Warimwe, TM Keane, G Fegan… - Proceedings of the …, 2009 - National Acad Sciences
Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) is a potentially important
family of immune targets, which play a central role in the host–parasite interaction by binding …

Cerebral Plasmodium falciparum malaria: The role of PfEMP1 in its pathogenesis and immunity, and PfEMP1‐based vaccines to prevent it

AR Jensen, Y Adams, L Hviid - Immunological reviews, 2020 - Wiley Online Library
Malaria, a mosquito‐borne infectious disease caused by parasites of the genus Plasmodium
continues to be a major health problem worldwide. The unicellular Plasmodium‐parasites …

Sequential, ordered acquisition of antibodies to Plasmodium falciparum erythrocyte membrane protein 1 domains

GKK Cham, L Turner, J Lusingu… - The Journal of …, 2009 - journals.aai.org
The binding of erythrocytes infected with mature blood stage parasites to the vascular bed is
key to the pathogenesis of malignant malaria. The binding is mediated by members of …

Induction of crossreactive antibodies against the Plasmodium falciparum variant protein

S Gratepanche, B Gamain, JD Smith… - Proceedings of the …, 2003 - National Acad Sciences
The variant antigen Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1),
present on the surface of P. falciparum-parasitized erythrocytes (PE), plays a central role in …

CD4 T Cell Responses to a Variant Antigen of the Malaria Parasite Plasmodium falciparum, Erythrocyte Membrane Protein-1, in Individuals Living in Malaria-Endemic …

CEM Allsopp, LA Sanni, L Reubsaet… - The Journal of …, 2002 - academic.oup.com
Plasmodium falciparum erythrocyte membrane protein-1 (PfEMP-1) is a variant antigen on
the surface of malaria-infected red blood cells. Antibody responses to PfEMP-1 correlate …

Comprehensive analysis of antibody responses to Plasmodium falciparum erythrocyte membrane protein 1 domains

BN Kanoi, H Nagaoka, M Morita, MT White… - Vaccine, 2018 - Elsevier
Acquired antibodies directed towards antigens expressed on the surface of merozoites and
infected erythrocytes play an important role in protective immunity to Plasmodium falciparum …

Limited Cross-Reactivity among Domains of the Plasmodium falciparum Clone 3D7 Erythrocyte Membrane Protein 1 Family

L Joergensen, L Turner, P Magistrado… - Infection and …, 2006 - Am Soc Microbiol
The var gene-encoded Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1)
family is responsible for antigenic variation and sequestration of infected erythrocytes during …