Cryptococcus neoformans is a pathogenic basidiomycetous yeast that can cause life-
threatening meningoencephalitis in immuno-compromized patients. To propagate in the …

Nutrient acquisition and sensing are critical aspects of microbial pathogenesis. Previous
transcriptional profiling indicated that the fungal pathogen Cryptococcus neoformans, which …

Phosphatases, together with kinases and transcription factors, are key components in
cellular signalling networks. Here, we present a systematic functional analysis of the …

A defect in the PKA1 gene encoding the catalytic subunit of cyclic adenosine 5′-
monophosphate (cAMP)–dependent protein kinase A (PKA) is known to reduce capsule size …

Cryptococcus neoformans survives host temperature and regulates cell wall integrity via a
calcium-dependent phosphatase, calcineurin. However, downstream effectors of C …

Phosphate acquisition by fungi is regulated by the phosphate-sensing and acquisition
(PHO) signaling pathway. Cryptococcus neoformans disseminates from the lung to the brain …

Eukaryotic cells utilize complex signaling systems to detect their environments, responding
and adapting as new conditions arise during evolution. The basidiomycete fungus …

Cryptococcus neoformans strains isolated from patients with AIDS secrete acid
phosphatase, but the identity and role of the enzyme (s) responsible have not been …

Nitrogen availability is vital for the growth and survival of Cryptococcus neoformans in the
natural environment. Two major ecological reservoirs were previously described for C …

Cryptococcosis is a fungal disease caused by C. neoformans. To adapt and survive in
diverse ecological niches, including the animal host, this opportunistic pathogen relies on its …