Macrolides are among the most widely prescribed broad spectrum antibacterials, particularly
for respiratory infections. It is now recognized that these drugs, in particular azithromycin …

Background: It has been recognized for more than 20 years that the macrolides have
immunomodulatory effects that are beneficial for those suffering from chronic pulmonary …

Macrolide antibiotics have potent immunomodulatory activity. The spectrum of action of
these antibiotics extends to regulation of leukocyte function and production of inflammatory …

Macrolide antibiotics administered in sub-antimicrobial doses improve pulmonary function
and decrease exacerbation frequency for persons with diffuse panbronchiolitis or cystic …

Macrolides have diverse biological activities and an ability to modulate inflammation and
immunity in eukaryotes without affecting homeostatic immunity. These properties have led to …

Macrolides can facilitate the killing of microorganisms in acute respiratory infections through
the stimulation of neutrophil activation. On long-term administration, anti-inflammatory, T …

Antibiotics represent our bulwark to combat bacterial infections, but the spread of antibiotic
resistance compromises their clinical efficacy. Alternatives to conventional antibiotics are …

Macrolides are widely used as antibacterial drugs. Clinical and experimental data, however,
indicate that they also modulate inflammatory responses, both contributing to the treatment …

Macrolide antibiotics are well known for their antibacterial and anti-inflammatory properties.
This article provides an overview of the biological mechanisms through which macrolides …

The macrolide antimicrobial family is a comprised of 14, 15 and 16 member-ringed
compounds that are characterized by similar chemical structures, mechanisms of action and …