[PDF][PDF] Treatment of rat gliomas with recombinant retrovirus harboring Herpes simplex virus thymidine kinase suicide gene
J Hlavaty, K Hlubinova, V Altanerova, J Liska… - Neoplasma, 1997 - researchgate.net
The retrovirus vector containing Herpes simplex virus type 1 thymidine kinase (HSV/A-)
gene was constructed. The vector was transfected into the packaging cell line PG13. It was …
gene was constructed. The vector was transfected into the packaging cell line PG13. It was …
Selective killing of glioma cells in culture and in vivo by retrovirus transfer of the herpes simplex virus thymidine kinase gene.
ZD Ezzeddine, RL Martuza, D Platika, MP Short… - The New …, 1991 - europepmc.org
The thymidine kinase gene (tk) of herpes simplex type 1 virus (HSV-1) was inserted into a
retroviral vector under the transcriptional control of the enhancer-promoter element of the …
retroviral vector under the transcriptional control of the enhancer-promoter element of the …
Human malignant brain tumor response to herpes simplex thymidine kinase (HSVtk)/ganciclovir gene therapy.
M Izquierdo, V Martin, P De Felipe, JM Izquierdo… - Gene therapy, 1996 - europepmc.org
Growing cells from human brain tumors have been treated in vitro and in vivo with murine
therapeutic retroviral producer cells. The therapeutic retrovirus carried the potential suicide …
therapeutic retroviral producer cells. The therapeutic retrovirus carried the potential suicide …
Gene therapy of maliganant brain tumors: A rat glioma line bearing the herpes simplex virus type 1‐thymidine kinase gene and wild type retrovirus kills other tumor …
Y Takamiya, MP Short, ZD Ezzeddine… - Journal of …, 1992 - Wiley Online Library
Tumor cells infected with a retrovirus vector (VIK) containing the herpes simplex virus
thymidine kinase (HSV‐TK) gene can be selectively killed by treatment with nucleoside …
thymidine kinase (HSV‐TK) gene can be selectively killed by treatment with nucleoside …
Treatment of glioblastoma by direct inoculation of concentrated high titer-recombinant retrovirus carrying the herpes simplex virus thymidine kinase gene.
K Ikenaka, M Sasaki, K Tamura, M Tamura, Y Miyao… - Human Cell, 2001 - europepmc.org
We prepared retroviruses carrying the lacZ gene or herpes simplex virus thymidine kinase
(HTK) gene with titers of 1.4-2.5 x 10 (11) colony-forming units (cfu)/ml, and stereotaxically …
(HTK) gene with titers of 1.4-2.5 x 10 (11) colony-forming units (cfu)/ml, and stereotaxically …
Curability of tumors bearing herpes thymidine kinase genes transfered by retroviral vectors
FL Moolten, JM Wells - JNCI: Journal of the National Cancer …, 1990 - academic.oup.com
Retroviral vectors constructed to contain the herpes simplex virus thymidine kinase (HSV-
TK) gene were used for transduction of this gene into murine sarcoma and lymphoma cells …
TK) gene were used for transduction of this gene into murine sarcoma and lymphoma cells …
Retrovirus-mediated gene therapy of experimental brain neoplasms using the herpes simplex virus-thymidine kinase/ganciclovir paradigm.
NG Rainov, CM Kramm, K Aboody-Guterman… - Cancer Gene …, 1996 - europepmc.org
Recent results in experimental brain tumors indicate that transfer of sensitizing genes to
tumor cells in vivo with subsequent drug treatment can reduce tumor masses and prolong …
tumor cells in vivo with subsequent drug treatment can reduce tumor masses and prolong …
Gene therapy for the treatment of brain tumors using intra-tumoral transduction with the thymidine kinase gene and intravenous ganciclovir. National Institutes of …
EH Oldfield, Z Ram, KW Culver, RM Blaese… - Human Gene …, 1993 - liebertpub.com
SCIENTIFIC ABSTRACT Murine retroviral vectors can infect a wide variety of proliferating
mammalian cell types (eg lymphocytes). Non-proliferating tissues (eg neurons) are not …
mammalian cell types (eg lymphocytes). Non-proliferating tissues (eg neurons) are not …
Eradication of murine brain tumors by direct inoculation of concentrated high titer-recombinant retrovirus harboring the herpes simplex virus thymidine kinase gene
K Tamura, M Tamura, K Ikenaka, T Yoshimatsu… - Gene Therapy, 2001 - nature.com
Implantation of retrovirus-producing cells within a tumor has been demonstrated to eliminate
malignant brain tumors effectively in animal models. In our previous study, the implantation …
malignant brain tumors effectively in animal models. In our previous study, the implantation …
An experimental model of retrovirus gene therapy for malignant brain tumors
Y Takamiya, MP Short, FL Moolten, C Fleet… - Journal of …, 1993 - thejns.org
✓ Recent research using rodent models of central nervous system gliomas indicates that a
combination of gene transfer and drug treatment may be successful in killing tumor cells. In …
combination of gene transfer and drug treatment may be successful in killing tumor cells. In …