The retrovirus vector containing Herpes simplex virus type 1 thymidine kinase (HSV/A-)
gene was constructed. The vector was transfected into the packaging cell line PG13. It was …

The thymidine kinase gene (tk) of herpes simplex type 1 virus (HSV-1) was inserted into a
retroviral vector under the transcriptional control of the enhancer-promoter element of the …

Growing cells from human brain tumors have been treated in vitro and in vivo with murine
therapeutic retroviral producer cells. The therapeutic retrovirus carried the potential suicide …

Tumor cells infected with a retrovirus vector (VIK) containing the herpes simplex virus
thymidine kinase (HSV‐TK) gene can be selectively killed by treatment with nucleoside …

We prepared retroviruses carrying the lacZ gene or herpes simplex virus thymidine kinase
(HTK) gene with titers of 1.4-2.5 x 10 (11) colony-forming units (cfu)/ml, and stereotaxically …

Retroviral vectors constructed to contain the herpes simplex virus thymidine kinase (HSV-
TK) gene were used for transduction of this gene into murine sarcoma and lymphoma cells …

Recent results in experimental brain tumors indicate that transfer of sensitizing genes to
tumor cells in vivo with subsequent drug treatment can reduce tumor masses and prolong …

SCIENTIFIC ABSTRACT Murine retroviral vectors can infect a wide variety of proliferating
mammalian cell types (eg lymphocytes). Non-proliferating tissues (eg neurons) are not …

Implantation of retrovirus-producing cells within a tumor has been demonstrated to eliminate
malignant brain tumors effectively in animal models. In our previous study, the implantation …

✓ Recent research using rodent models of central nervous system gliomas indicates that a
combination of gene transfer and drug treatment may be successful in killing tumor cells. In …