Research into the basic effects and therapeutic applications of psychedelic drugs has grown
considerably in recent years. Yet, pressing questions remain regarding the substances' …

Psychedelics represent one of the most promising classes of experimental medicines for the
treatment of neuropsychiatric disorders due to their ability to promote neural plasticity and …

The serotonergic classical psychedelics include compounds that primarily activate the
brain's serotonin 2 A receptor (5-HT2AR), such as LSD, psilocybin, and DMT (ayahuasca) …

The purpose of this commentary is to provide an introduction to this special issue of
Neuropharmacology with a historical perspective of psychedelic drug research, their use in …

Survey-based studies suggest naturalistic psychedelic use provides mental health benefits
similar to those observed in clinical trials. The current study sought to confirm these findings …

Background: Over the last two decades, a number of studies have highlighted the potential
of psychedelic therapy. However, questions remain to what extend these results translate to …

In the last 15 years, psychedelic substances, such as LSD and psilocybin, have regained
legitimacy in clinical research. In the general population as well as across various …

Renewed interest in the effects of psychedelics in the treatment of psychiatric disorders
warrants a better understanding of the neurobiological mechanisms underlying the effects of …

This paper provides a critical review of several possible mechanisms at different levels of
analysis underlying the effects and therapeutic potential of psychedelics. At the (1) …

Classical psychedelics, primarily psilocybin and lysergic acid diethylamide (LSD), have
been used and extensively studied in Western medicine as part of substance-assisted …