The innate immune system is dysregulated in depression; however, less is known about the
longitudinal associations of depression and inflammatory biomarkers. We investigated the …

Background Inflammatory markers are raised in cross-sectional studies of depressed
patients and may represent an important mediating factor for behaviour, neural plasticity and …

Background While cross-sectional associations of inflammatory markers interleukin-6 (IL-6)
and C-reactive protein with major depressive disorder are well established, evidence for …

Background The direction of the association between inflammation and depressive
symptoms remains inconsistent. The objective of this study was to evaluate the temporal …

Objective: To assess the magnitude and direction of associations of depression with C-
reactive protein (CRP), interleukin (IL)-1, and IL-6 in community and clinical samples …

Objective: Evidence from anti-inflammatory drug trials for the treatment of depression has
been inconsistent. This may be ascribed to the differing symptom-specific effects of …

Importance The magnitude and variability of cytokine alterations in depression are not clear.
Objective To perform an up to date meta-analysis of mean differences of immune markers in …

Background/Aim Depression has become a multiple disease worldwide, and is closely
related to the systemic inflammatory response. Methods Based on the data of the National …

Rationale Evidence suggests that depression is cross-sectionally and longitudinally
associated with activation of inflammatory response system. A few studies, however, have …

Cumulative meta-analyses are used to evaluate the extent to which further studies are
needed to confirm or refute a hypothesis. We used this approach to assess observational …