Persistent low-grade inflammation and premature ageing are hallmarks of the uremic
phenotype and contribute to impaired health status, reduced quality of life, and premature …

Systemic inflammation in end-stage renal disease is an established risk factor for mortality
and a catalyst for other complications, which are related to a premature aging phenotype …

Chronic kidney disease (CKD) will progress to end stage without treatment, but the decline
of renal function may not be linear. Compared with glomerular filtration rate and proteinuria …

Chronic kidney disease (CKD), defined as the presence of irreversible structural or
functional kidney damages, increases the risk of poor outcomes due to its association with …

Despite recent advances in the management of chronic kidney disease (CKD), morbidity
and mortality rates in these patients remain high. While pressure-mediated injury is a well …

Significance: Chronic kidney disease (CKD) can be regarded as a burden of lifestyle
disease that shares common underpinning features and risk factors with the aging process; …

Cardiovascular diseases (CVDs), especially those involving a systemic inflammatory
process such as atherosclerosis, remain the leading cause of morbidity and mortality in …

Kidney lifespan is a patient-oriented outcome that provides much needed context for
understanding chronic kidney disease (CKD). Nephron endowment, age-associated decline …

Systemic inflammation is a condition intrinsically linked to chronic kidney disease (CKD) and
its other typical sequelae, such as acquired immune dysfunction, protein-energy wasting …

Epidemiologic, clinical, and molecular evidence suggest that aging is a major contributor to
the increasing incidence of acute kidney injury and chronic kidney disease. The aging …