Cancer is one of the leading causes of death globally according to the World Health
Organization. Although improved treatments and early diagnoses have reduced cancer …

The progression of breast cancer from the primary tumor setting to the metastatic setting is
the critical event defining Stage IV disease, no longer considered curable. The …

Highlights⿢The tumor microenvironment regulates tumor initiation, progression, and
metastasis.⿢We summarize the use of biomaterials in tumor modeling in vitro.⿢Engineered …

Clinical evidence supports a role for the extracellular matrix (ECM) in cancer plasticity
across multiple tumor types. The lack of in vitro models that represent the native ECMs is a …

The use of biomaterials has substantially contributed to both our understanding of
tumorigenesis and our ability to identify and capture tumour cells in vitro and in vivo. Natural …

The metastatic cascade presents a significant challenge to patient survival in the fight
against cancer. As metastatic cells disseminate and colonize a secondary site, stepwise …

One of the hurdles to the development of new anticancer therapies is the lack of in vitro
models which faithfully reproduce the in vivo tumor microenvironment (TME). Understanding …

The coordinated migration of invasive tumor cells is a complex and dynamic mechanism
driven by diverse cellular and molecular events. Unfortunately, the inherent heterogeneity …

Despite decades of research and advancements in diagnostic and treatment modalities,
cancer remains a major global healthcare challenge. This is due in part to a lack of model …

Prevailing evidence has established the fundamental role of microenvironmental conditions
in tumorigenesis. However, the ability to identify, interrupt, and translate the underlying …