Background. Beta-lactam antibiotics are a commonly used treatment for severe sepsis, with
intermittent bolus dosing standard therapy, despite a strong theoretical rationale for …

Rationale: Optimization of β-lactam antibiotic dosing for critically ill patients is an intervention
that may improve outcomes in severe sepsis. Objectives: In this individual patient data meta …

Rationale: Continuous infusion of β-lactam antibiotics may improve outcomes because of
time-dependent antibacterial activity compared with intermittent dosing. Objectives: To …

Purpose This study aims to determine if continuous infusion (CI) is associated with better
clinical and pharmacokinetic/pharmacodynamic (PK/PD) outcomes compared to intermittent …

Background and rationale: β-Lactam antibiotics display a time-dependent mechanism of
action, with evidence suggesting improved outcomes when administering these drugs via …

Background The prolonged β-lactam infusion strategy has emerged as the standard
treatment for sepsis or septic shock despite its unknown efficacy. This study aimed to assess …

The optimal approach for empirical antibiotic therapy in patients with severe sepsis and
septic shock remains controversial. A retrospective cohort study was conducted in the …

Objectives: Compelling evidence has shown that aggressive resuscitation bundles,
adequate source control, appropriate antibiotic therapy, and organ support are cornerstone …

Background In patients with severe sepsis, no randomized clinical trial has tested the
concept of de-escalation of empirical antimicrobial therapy. This study aimed to compare the …

Sepsis is a medical emergency and life-threatening condition due to a dysregulated host
response to infection, which is time-dependent and associated with unacceptably high …