MR-guided focused ultrasound (MRgFUS), in combination with intravenous microbubble
administration, has been applied for focal temporary BBB opening in patients with …

OBJECTIVE MRI-guided low-intensity focused ultrasound (FUS) has been shown to
reversibly open the blood-brain barrier (BBB), with the potential to deliver therapeutic agents …

MR-guided focused ultrasound (MRgFUS) can temporarily permeabilize the blood-brain
barrier (BBB), noninvasively, to allow therapeutics access to the central nervous system …

The blood–brain barrier (BBB) protects the brain but is also an important obstacle for the
effective delivery of therapeutics in Alzheimer's disease and other neurodegenerative …

The blood–brain barrier (BBB) presents a significant challenge for treating brain disorders.
The hippocampus is a key target for novel therapeutics, playing an important role in …

Background Parkinson's disease (PD) exhibits a high prevalence of dementia as disease
severity and duration progress. Focused ultrasound (FUS) has been applied for transient …

Background Focused ultrasound (FUS)-mediated blood–brain barrier (BBB) opening has
shown efficacy in removal of amyloid plaque and improvement of cognitive functions in …

Blood-brain barrier (BBB) remains a significant obstacle to drug therapy for brain diseases.
Focused ultrasound (FUS) combined with microbubbles (MBs) can locally and transiently …

Background Opening of the blood-brain barrier (BBB) induced with MRI-guided focused
ultrasound has been shown in experimental animal models to reduce amyloid-β plaque …

MR-guided focused ultrasound (MRgFUS) is an emerging technology that can accurately
and transiently permeabilize the blood-brain barrier (BBB) for targeted drug delivery to the …