Identifying potential drug targets for varicose veins through integration of GWAS and eQTL summary data

Y Cui, M Hu, H Zhou, J Guo, Q Wang, Z Xu… - Frontiers in …, 2024 - frontiersin.org
Background Varicose veins (VV) are a common chronic venous disease that is influenced by
multiple factors. It affects the quality of life of patients and imposes a huge economic burden …

Genome-wide association analysis and replication in 810,625 individuals identifies novel therapeutic targets for varicose veins

WUR Ahmed, A Wiberg, M Ng, W Wang, A Auton… - BioRxiv, 2020 - biorxiv.org
Abstract Background Varicose veins (VVs) affect one-third of Western society, with a
significant subset of patients developing venous ulceration, and ongoing management of …

Identification of potential drug targets for varicose veins: a Mendelian randomization analysis

J Lin, J Zhou, Z Liu, R Zeng, L Wang, F Li… - Frontiers in …, 2023 - frontiersin.org
Introduction Varicose veins are a common chronic disease that creates a significant
economic burden on the healthcare system. Current treatment options, including …

Genome-wide association study of varicose veins identifies a protective missense variant in GJD3 enriched in the Finnish population

P Helkkula, S Hassan, E Saarentaus… - Communications …, 2023 - nature.com
Varicose veins is the most common manifestation of chronic venous disease that displays
female-biased incidence. To identify protein-inactivating variants that could guide …

Genome-wide association analysis and replication in 810,625 individuals with varicose veins

WUR Ahmed, S Kleeman, M Ng, W Wang… - Nature …, 2022 - nature.com
Varicose veins affect one-third of Western society, with a significant subset of patients
developing venous ulceration, costing $14.9 billion annually in the USA. Current …

A genome-wide association study for varicose veins

ML Lee, C Liang, CH Chuang, PS Lee, TH Chen… - …, 2022 - journals.sagepub.com
Background The aim was to compare the genetic information of varicose vein patients with
that of a healthy population attempting to identify certain significant genetic associations …

Polymorphisms of genes involved in inflammation and blood vessel development influence the risk of varicose veins

A Shadrina, Y Tsepilov, M Smetanina… - Clinical …, 2018 - Wiley Online Library
Heredity plays an important role in the etiology of varicose veins (VVs). However, the genetic
basis underlying this condition remains poorly understood. Our aim was to replicate top …

Varicose veins of lower extremities: Insights from the first large-scale genetic study

AS Shadrina, SZ Sharapov, TI Shashkova… - PLoS …, 2019 - journals.plos.org
Varicose veins of lower extremities (VVs) are a common multifactorial vascular disease.
Genetic factors underlying VVs development remain largely unknown. Here we report the …

Pathophysiology and Genetic Associations of Varicose Veins: A Narrative Review

T Chen, P Liu, C Zhang, S Jin, Y Kong, Y Feng… - Angiology, 2024 - journals.sagepub.com
Varicose veins (VVs) have a high prevalence worldwide and have become a major medical
burden. Their pathophysiology involves a complex interplay of inflammation and tissue …

Integrative analysis prioritizes the relevant genes and risk factors for chronic venous disease

R He, H Cai, Y Jiang, R Liu, Y Zhou, Y Qin… - Journal of Vascular …, 2022 - Elsevier
Objective Chronic venous disease (CVD) refers to a range of symptoms resulting from long-
term morphological and functional abnormalities of the venous system. However, the …