This study explored the hypothesis that intracerebral hemorrhage (ICH) promotes release of
diffusible factors that can significantly influence the structure and function of cerebral arteries …

Platelet-derived growth factor (PDGF) has been implicated in the pathogenesis of cerebral
vasospasm after subarachnoid hemorrhage (SAH), but the mechanism remains unknown …

Intracerebral hemorrhage (ICH) represents the deadliest subtype of all strokes. The
development of brain edema, a consequence of blood–brain barrier (BBB) disruption, is the …

Blood–brain barrier (BBB) disruption and consequent edema formation contribute to the
development of early brain injury following subarachnoid hemorrhage (SAH). Various …

Elevated blood pressure (BP) is commonly seen in patients with intracerebral hemorrhage
(ICH), and is independently associated with poor functional outcomes. Little is known about …

Background and Purpose—Insulin-like growth factor (IGF) treatment has been shown to
have trophic and neuroprotective effects in vitro and in vivo in different lesion models. IGF-I …

Oxidative stress and matrix metalloproteinases (MMPs) contribute to hemorrhagic
transformation after ischemic stroke and brain injury after intracerebral hemorrhage (ICH) …

Background: Angiogenesis is essential for the repair process after intracerebral hemorrhage
(ICH). Methods: Given the importance of the extracellular matrix (ECM) in angiogenesis, we …

Our previous studies showed that Insulin-like Growth Factor (IGF)-1 reduced blood brain
barrier permeability and decreased infarct volume caused by middle cerebral artery …

Background Intracerebral hemorrhage (ICH) is an acute neurological disorder with high
mortality and no effective treatment. In addition to the initial bleeding event, rebleeding and …