Predictive value of the 4Ts scoring system for heparin-induced thrombocytopenia: a systematic review and meta-analysis

A Cuker, PA Gimotty, MA Crowther… - Blood, The Journal of …, 2012 - ashpublications.org
The 4Ts is a pretest clinical scoring system for heparin-induced thrombocytopenia (HIT).
Although widely used in clinical practice, its predictive value for HIT in diverse settings and …

[HTML][HTML] The HIT Expert Probability (HEP) Score: a novel pre‐test probability model for heparin‐induced thrombocytopenia based on broad expert opinion

A Cuker, G Arepally, MA Crowther, L Rice… - Journal of thrombosis …, 2010 - Elsevier
Background: The diagnosis of heparin‐induced thrombocytopenia (HIT) is challenging. Over‐
diagnosis and over‐treatment are common. Objectives: To develop a pre‐test clinical …

Combination of 4Ts score and PF4/H-PaGIA for diagnosis and management of heparin-induced thrombocytopenia: prospective cohort study

LA Linkins, SM Bates, AYY Lee… - Blood, The Journal …, 2015 - ashpublications.org
Rapid exclusion of heparin-induced thrombocytopenia (HIT) is needed to determine which
patients can continue to receive heparin. In this prospective management study, 526 …

Clinical and laboratory diagnosis of heparin-induced thrombocytopenia: an integrated approach

A Cuker - Seminars in thrombosis and hemostasis, 2014 - thieme-connect.com
Heparin-induced thrombocytopenia (HIT) is a clinicopathologic disorder that predisposes to
thrombosis. Diagnosis rests on a compatible clinical picture and laboratory evidence of …

[HTML][HTML] Prospective evaluation of the '4Ts' score and particle gel immunoassay specific to heparin/PF4 for the diagnosis of heparin‐induced thrombocytopenia

C Pouplard, P Gueret, M Fouassier, C Ternisien… - Journal of Thrombosis …, 2007 - Elsevier
Background: Heparin‐induced thrombocytopenia (HIT) is a severe disease that is often
difficult to diagnose. A clinical scoring system, the '4Ts' score, has been proposed to …

[HTML][HTML] Evaluation of pretest clinical score (4 T's) for the diagnosis of heparin‐induced thrombocytopenia in two clinical settings

GK Lo, D Juhl, TE Warkentin, CS Sigouin… - Journal of Thrombosis …, 2006 - Elsevier
Background: Heparin‐induced thrombocytopenia (HIT) is a prothrombotic adverse drug
reaction caused by heparin. As thrombocytopenia is common in hospitalized patients …

Diagnostic value of immunoassays for heparin-induced thrombocytopenia: a systematic review and meta-analysis

M Nagler, LM Bachmann, H Ten Cate… - Blood, The Journal …, 2016 - ashpublications.org
Immunoassays are essential in the workup of patients with suspected heparin-induced
thrombocytopenia. However, the diagnostic accuracy is uncertain with regard to different …

The 4Ts scoring system for heparin-induced thrombocytopenia in medical-surgical intensive care unit patients

MA Crowther, DJ Cook, M Albert, D Williamson… - Journal of critical …, 2010 - Elsevier
BACKGROUND: Heparin-induced thrombocytopenia (HIT) is commonly considered but
rarely confirmed in critically ill patients. The 4Ts score (Thrombocytopenia, Timing of …

Diagnostic accuracy of rapid immunoassays for heparin-induced thrombocytopenia

L Sun, PA Gimotty, S Lakshmanan… - Thrombosis and …, 2016 - thieme-connect.com
The platelet factor 4/heparin ELISA has limited specificity for heparininduced
thrombocytopenia (HIT) and frequently does not provide same-day results. Rapid …