Genome-wide mapping of spontaneous genetic alterations in diploid yeast cells
Genomic alterations including single-base mutations, deletions and duplications,
translocations, mitotic recombination events, and chromosome aneuploidy generate genetic …
translocations, mitotic recombination events, and chromosome aneuploidy generate genetic …
The genome-wide rate and spectrum of spontaneous mutations differ between haploid and diploid yeast
By altering the dynamics of DNA replication and repair, alternative ploidy states may
experience different rates and types of new mutations, leading to divergent evolutionary …
experience different rates and types of new mutations, leading to divergent evolutionary …
Variable spontaneous mutation and loss of heterozygosity among heterozygous genomes in yeast
Mutation and recombination are the primary sources of genetic variation. To better
understand the evolution of genetic variation, it is crucial to comprehensively investigate the …
understand the evolution of genetic variation, it is crucial to comprehensively investigate the …
A genome-wide view of the spectrum of spontaneous mutations in yeast
The mutation process ultimately defines the genetic features of all populations and, hence,
has a bearing on a wide range of issues involving evolutionary genetics, inheritance, and …
has a bearing on a wide range of issues involving evolutionary genetics, inheritance, and …
Genome Dynamics of Hybrid Saccharomyces cerevisiae During Vegetative and Meiotic Divisions
Mutation and recombination are the major sources of genetic diversity in all organisms. In
the baker's yeast, all mutation rate estimates are in homozygous background. We …
the baker's yeast, all mutation rate estimates are in homozygous background. We …
[HTML][HTML] Spontaneous changes in ploidy are common in yeast
Changes in ploidy are relatively rare, but play important roles in the development of cancer
and the acquisition of long-term adaptations. Genome duplications occur across the tree of …
and the acquisition of long-term adaptations. Genome duplications occur across the tree of …
High-resolution genome-wide analysis of irradiated (UV and γ-rays) diploid yeast cells reveals a high frequency of genomic loss of heterozygosity (LOH) events
J St. Charles, E Hazkani-Covo, Y Yin, SL Andersen… - Genetics, 2012 - academic.oup.com
In diploid eukaryotes, repair of double-stranded DNA breaks by homologous recombination
often leads to loss of heterozygosity (LOH). Most previous studies of mitotic recombination in …
often leads to loss of heterozygosity (LOH). Most previous studies of mitotic recombination in …
[HTML][HTML] The baker's yeast diploid genome is remarkably stable in vegetative growth and meiosis
Accurate estimates of mutation rates provide critical information to analyze genome
evolution and organism fitness. We used whole-genome DNA sequencing, pulse-field gel …
evolution and organism fitness. We used whole-genome DNA sequencing, pulse-field gel …
[HTML][HTML] Genome-wide consequences of deleting any single gene
Loss or duplication of chromosome segments can lead to further genomic changes
associated with cancer. However, it is not known whether only a select subset of genes is …
associated with cancer. However, it is not known whether only a select subset of genes is …
[HTML][HTML] Loss of heterozygosity results in rapid but variable genome homogenization across yeast genetic backgrounds
A Dutta, F Dutreux, J Schacherer - Elife, 2021 - elifesciences.org
The dynamics and diversity of the appearance of genetic variants play an essential role in
the evolution of the genome and the shaping of biodiversity. Recent population-wide …
the evolution of the genome and the shaping of biodiversity. Recent population-wide …