Pancreatic ductal adenocarcinoma (PDAC) has one of the worst prognoses among all
malignancies. PI3K/AKT/mTOR signaling pathway, a main downstream effector of KRAS is …

Although pancreatic cancer (PC) was considered in the past an orphan cancer type due to
its low incidence, it may become in the future one of the leading causes of cancer death …

Simple Summary Pancreatic cancer has a dismal 5-year survival rate of 10%, making it one
of the deadliest forms of malignancy. The poor prognosis associated with this disease is …

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy characterized
by its sudden manifestation, rapid progression, poor prognosis, and limited therapeutic …

The phosphoinositide 3 kinase AKT mammalian target of rapamycin (PI3K-AKTmTOR)
signaling pathway is an important in the aetiology of pancreatic cancer (PC) and is …

Pancreatic cancer belongs to the incurable family of solid cancers. Despite of a recent better
understanding its molecular biology, and an increased number of clinical trials, there is still a …

Cancer is a severe public health issue that is a leading cause of mortality globally. It is also
an impediment to improving life expectancy worldwide. Furthermore, the global burden of …

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy and is highly
resistant to standard treatment regimens. Targeted therapies against KRAS, a mutation …

Patients with pancreatic cancer have dismal prognoses, and novel therapies are urgently
needed. Mutations of the KRAS oncogene occur frequently in pancreatic cancer and …

Aberrations in the phosphoinositide 3-kinase (PI3K) signaling pathway have a key role in
the pathogenesis of numerous cancers by altering cell growth, metabolism, proliferation and …