Implications of estrogen and its receptors in colorectal carcinoma
Estrogens have been implicated in the pathogenesis of various cancer types, including
colorectal carcinoma (CRC). Estrogen receptors such as ERα and ERβ activate intracellular …
colorectal carcinoma (CRC). Estrogen receptors such as ERα and ERβ activate intracellular …
[HTML][HTML] Estrogen receptors and their implications in colorectal carcinogenesis
Upon binding their cognate receptors, ERα (ESR1) and ERβ (ESR2), estrogens activate
intracellular signaling cascades that have important consequences for cellular behavior …
intracellular signaling cascades that have important consequences for cellular behavior …
Molecular pathways: estrogen pathway in colorectal cancer
A Barzi, AM Lenz, MJ Labonte, HJ Lenz - Clinical cancer research, 2013 - AACR
Worldwide, colorectal cancer has a higher incidence rate in men than in women, suggesting
a protective role for sex hormones in the development of the disease. Preclinical data …
a protective role for sex hormones in the development of the disease. Preclinical data …
[HTML][HTML] Targeting estrogen receptors in colorectal cancer
JW Maingi, S Tang, S Liu, W Ngenya, E Bao - Molecular Biology Reports, 2020 - Springer
Hormones have become a useful therapeutic aspect of clinical endocrinology but how to use
them to optimize the health benefits and avoid adverse effects is a major challenge …
them to optimize the health benefits and avoid adverse effects is a major challenge …
[HTML][HTML] Estrogen receptors in colorectal cancer: Facts, novelties and perspectives
I Ditonno, G Losurdo, M Rendina, M Pricci, B Girardi… - Current …, 2021 - mdpi.com
Colorectal cancer (CRC) is the second cause of cancer-related death in both sexes
worldwide. As pre-menopausal women are less likely to develop CRC compared to age …
worldwide. As pre-menopausal women are less likely to develop CRC compared to age …
Estrogen receptor β induces antiinflammatory and antitumorigenic networks in colon cancer cells
K Edvardsson, A Ström, P Jonsson… - Molecular …, 2011 - academic.oup.com
Several studies suggest estrogen to be protective against the development of colon cancer.
Estrogen receptor β (ERβ) is the predominant estrogen receptor expressed in colorectal …
Estrogen receptor β (ERβ) is the predominant estrogen receptor expressed in colorectal …
[HTML][HTML] ERβ is a potent inhibitor of cell proliferation in the HCT8 human colon cancer cell line through regulation of cell cycle components
V Martineti, L Picariello, I Tognarini… - Endocrine-related …, 2005 - erc.bioscientifica.com
Several strands of evidence indicate that oestrogens exert a protective role against the
development of colon cancer through indirect and direct effects on colonic epithelium …
development of colon cancer through indirect and direct effects on colonic epithelium …
Oestrogen receptor beta (ERβ) is abundantly expressed in normal colonic mucosa, but declines in colon adenocarcinoma paralleling the tumour's dedifferentiation
PA Konstantinopoulos, A Kominea, G Vandoros… - European journal of …, 2003 - Elsevier
Oestrogen Receptor β (ERβ) may protect against prostate and mammary cell proliferation
and malignant transformation. Epidemiological studies indicate that oestrogens may reduce …
and malignant transformation. Epidemiological studies indicate that oestrogens may reduce …
[HTML][HTML] Estrogen receptor beta as target for colorectal cancer prevention
Colorectal cancer (CRC) is a leading cause of death in the United States. Despite its slow
development and the capacity for early diagnosis, current preventive approaches are not …
development and the capacity for early diagnosis, current preventive approaches are not …
Selective loss of estrogen receptor β in malignant human colon
EF Foley, AA Jazaeri, MA Shupnik, O Jazaeri, LW Rice - Cancer Research, 2000 - AACR
Epidemiological data suggest a protective effect for estrogen replacement therapy on colon
cancer. The estrogen receptor (ER) is required for the action of estrogen. The ER-β isoform …
cancer. The estrogen receptor (ER) is required for the action of estrogen. The ER-β isoform …