The cytoplasmic protein-tyrosine kinase BTK plays an essential role for differentiation and
survival of B-lineage cells and, hence, represents a suitable drug target. The number of BTK …

Bruton's tyrosine kinase (BTK) regulates multiple important signaling pathways and plays a
key role in the proliferation, survival, and differentiation of B-lineage cells and myeloid cells …

Bruton's tyrosine kinase (BTK) represented, in the past ten years, an important target for the
development of new therapeutic agents that could be useful for cancer and autoimmune …

The use of Bruton's tyrosine kinase (BTK) inhibitors has changed the management of
patients with B-cell lymphoid malignancies. BTK is an important molecule that interconnects …

Bruton's tyrosine kinase (BTK) is a non-receptor kinase that plays a crucial role in oncogenic
signaling that is critical for proliferation and survival of leukemic cells in many B cell …

Bruton´ s tyrosine kinase (BTK) inhibitor (BTKi) s block the B-cell receptor (BCR) signaling
cascade by binding to the BTK enzyme preventing the proliferation and survival of malignant …

Background: Bruton tyrosine kinase (BTK) is a validated target for B-cell malignancies. The
BTK inhibitor ibrutinib was approved in chronic lymphocytic leukemia, mantle cell lymphoma …

Therapy based on Bruton's tyrosine kinase (BTK) inhibitors one of the major treatment
options currently recommended for lymphoma patients. The first generation of BTK inhibitor …

Small molecule inhibitors targeting dysregulated pathways (RAS/RAF/MEK,
PI3K/AKT/mTOR, JAK/STAT) have significantly improved clinical outcomes in cancer …

Dear Editor, Non-HodgkinLs lymphoma (NHL) is a type of cancer that mainly develops from
B-cell malignancies, causing 231,400 deaths in 2015 globally. According to the American …