Sickle cell disease is a hemoglobinopathy resulting from a point mutation from glutamate to
valine at position six of the β‐globin chains of hemoglobin. This mutation gives rise to …

Protein aggregation is associated with various diseases, including Alzheimer and Parkinson
as well as sickle cell disease (SCD). From a molecular point of view, protein aggregation …

Sickle cell anemia is the first disease whose genetic cause was pinpointed at the DNA level
[7]. Sickle cell disease is caused by the switch of a single DNA base pair in the hemoglobin …

In sickle cell anemia, deoxyhemoglobin deforms RBCs by forming fibrils inside that
disintegrate on oxygenation. We studied 100 ns long all-atom molecular dynamics (MD) for …

We compare the role of a conformational switch and that of a point mutation in the
thermodynamic stability of a protein solution and in the consequent propensity toward …

Sickle cell disease is a genetic disorder associated with a single mutation (Glu-β6→ Val-β6)
in the β chains of hemoglobin, causing the polymerization of deoxygenated sickle cell …

Molecular dynamics simulations have been used to investigate the thermodynamic stability
of axial contacts in sickle-cell hemoglobin (HbS). Free energy changes were evaluated for …

Sickle cell anemia is the first disease whose cause was pinpointed at a genetic level.
Hydrophobic interaction is the main cause for sickle hemoglobin (hemoglobin S) sticking to …

Sickle cell disease is a monogenic blood disorder associated with a mutation in the HBB
gene encoding for the β-globin of normal adult hemoglobin (HbA). This mutation transcribes …

Understanding the physical basis of protein aggregation covers strong physical and
biomedical interests. Sickle hemoglobin (HbS) is a point‐mutant form of normal human adult …