Cell lines and primary cultures from several teleost tissues and species were stained for
senescence-associated β-galactosidase (SA β-Gal), revealing four general outcomes.(1) For …

During the aging process, cells can enter cellular senescence, a state in which cells leave
the cell cycle but remain viable. This mechanism is thought to protect tissues from …

Cytochemically detectable β-galactosidase (β-gal) at pH 6.0 has been reported to increase
during the replicative senescence of fibroblast cultures and has been used widely as a …

Senescence-associated beta-galactosidase (SA-β-GAL) is an enzyme that accumulates in
the lysosomes of senescent cells, where it hydrolyses β-galactosides. With p16, it represents …

During vertebrate embryonic development, cellular senescence occurs at multiple locations.
To date, it has been accepted that when there has been induction of senescence in an …

Background Senescence‐associated β‐galactosidase (SA‐β‐GAL) histochemistry is the
most commonly used biomarker of cellular senescence. These SA‐β‐GAL‐positive cells are …

Senescence-associated β-galactosidase (hereafter SA-β-gal) staining has now been
employed for more than 20 years to identify the presence of senescent cells (Dimri et al …

Senescence-associated β-galactosidase (SA-β-gal) serves as a marker of senescence in
aging somatic cells. However, little is known about SA-β-gal dynamics in aging gamete cells …

Normal cells can permanently lose the ability to proliferate when challenged by potentially
oncogenic stress, a process termed cellular senescence. Senescence-associated beta …

A β-galactosidase activity has recently been used as a histochemical marker of replicative
senescence in human fibroblasts and keratinocytes. To establish whether this marker could …