Modern toxicology calls for in vitro solutions that reduce the need for animal testing, are
more human-relevant, high throughput, and cost effective. Immortalised human cell lines are …

The immortalised human hepatocellular HepG2 cell line is commonly used for toxicology
studies as an alternative to animal testing due to its characteristic liver-distinctive functions …

Liver toxicity is a leading systemic toxicity of drugs and chemicals demanding more human-
relevant, high throughput, cost effective in vitro solutions. In addition to contributing to animal …

Cell-based metabolomics provides multiparametric physiologically relevant readouts that
can be highly advantageous for improved, biologically based decision making in early …

Cell-based metabolomics provides multiparametric physiologically relevant readouts that
can be highly advantageous for improved, biologically based decision making in early …

NMR spectroscopy was used to evaluate growth media and the cellular metabolome in two
systems of interest to biomedical research. The first of these was a Chinese hamster ovary …

Omics technologies, and in particular metabolomics, have received an increasing attention
during the assessment of hepatotoxicity in vitro. However, at present, a consensus on good …

Background In vitro cell systems together with omics methods represent promising
alternatives to conventional animal models for toxicity testing. Transcriptomic and proteomic …

Toxicity studies, among them hepatotoxicity, are key throughout preclinical stages of drug
development to minimise undesired toxic effects that might eventually appear in the course …

Hepatotoxicity is the number one cause for agencies not approving and withdrawing drugs
for the market. Drug‐induced human hepatotoxicity frequently goes undetected in preclinical …