Seizures, particularly first onset seizures in adults, are a diagnostic hallmark of brain tumors
(Giglio and Villano, 2010). Unfortunately, malignant brain tumors are almost uniformly fatal …

Background Malignant brain tumors affect people of all ages and are the second leading
cause of cancer deaths in children. While current treatments are effective and improve …

Background Malignant brain cancer persists as a major disease of morbidity and mortality in
adults and is the second leading cause of cancer death in children. Many current therapies …

Information is presented on the calorically restricted ketogenic diet (CRKD) as an alternative
therapy for brain cancer. In contrast to normal neurons and glia, which evolved to metabolize …

Background The successful treatment of malignant gliomas remains a challenge despite the
current standard of care, which consists of surgery, radiation and temozolomide. Advances …

Abstract Purpose of Review In this review, we examine the postulated mechanisms of
therapeutic effect of ketogenic diets in the treatment of gliomas, review the completed clinical …

Advances in our understanding of glioma biology has led to an increase in targeted
therapies in preclinical and clinical trials; however, cellular heterogeneity often precludes …

Background: A high-fat, low-carbohydrate diet, often referred to as a ketogenic diet (KD), has
been suggested to reduce frequency and severity of chronic pediatric and adult seizures. A …

Survival of glioblastoma multiforme (GBM) with the current recommended treatment is poor.
Reported median survivals are approximately 8–15 months. Based on recent publications …

Malignant brain cancer persists as a major disease of morbidity and mortality. The failure to
recognize brain cancer as a disease of energy metabolism has contributed in large part to …