The different niches through which bacteria move during their life cycle require a fast
response to the many environmental queues they encounter. The sensing of these stimuli …

For many regulators of bacterial biodegradation pathways, small molecule/effector binding is
the signal for triggering transcriptional activation. Thus, regulation results from a cross-talk …

The active and inactive state of transcription factors in growing cells is usually directed by
allosteric physicochemical signals or metabolites, which are in turn either produced in the …

Bacteria possess a large number of signal transduction systems that sense and respond to
different environmental cues. Most frequently these are transcriptional regulators, two …

Bacteria are the most ancient and abundant organisms on the earth. Whereas bacterial
organisms served as first cellular model systems for explorations of genetic control by …

Bacteria have evolved many different signal transduction systems that sense signals and
generate a variety of responses. Generally, most abundant are transcriptional regulators …

Genomics, which has been identified as the science of the century, is dramatically changing
the historically weak relationship between experimental and theoretical biology. The …

Gene expression occurs in two essential steps: transcription and translation. In bacteria, the
two processes are tightly coupled in time and space, and highly regulated. Tight regulation …

Bacteria sense intracellular and environmental signals using an array of proteins as
antennas. The information is transmitted from such sensory modules to other protein …

Allosteric regulation is found across all domains of life, yet we still lack simple, predictive
theories that directly link the experimentally tunable parameters of a system to its input …