Deciphering the genetic landscape of Alzheimer's disease (AD) is essential to define the
pathophysiological pathways involved and to successfully translate genomics to potential …

Background Alzheimer's disease (AD) is a complex multifactorial neurodegenerative
disorder and the most common form of dementia. AD is highly heritable, with heritability …

Alzheimer's disease (AD) is the most common neurodegenerative disease and, owing to its
increasing prevalence, represents one of the leading public health problems in aging …

A large fraction of genetic risk factors for Alzheimer's Disease (AD) is still not identified,
limiting the understanding of AD pathology and study of therapeutic targets. We conducted a …

Alzheimer's disease (AD) is highly heritable and recent studies have identified over 20
disease-associated genomic loci. Yet these only explain a small proportion of the genetic …

Over 25 genes are known to affect the risk of developing Alzheimer disease (AD), the most
common neurodegenerative dementia. However, mechanistic insights and improved …

Abstract Characterization of the genetic landscape of Alzheimer's disease (AD) and related
dementias (ADD) provides a unique opportunity for a better understanding of the associated …

Background Genome-wide association studies (GWAS) have identified over 56 susceptibility
loci associated with Alzheimer's disease (AD), but the genes responsible for these …

Late-onset Alzheimer's disease is a prevalent age-related polygenic disease that accounts
for 50-70% of dementia cases. Late-onset Alzheimer's disease is caused by a combination …

Abstract Purpose of Review We aimed to summarize the recent advances in genetic findings
of Alzheimer's disease (AD), focusing on traditional single-marker and gene approaches …