Despite continuous advances in understanding the underlying pathogenesis of
hyperexcitable networks and lowered seizure thresholds, the treatment of epilepsy remains …

Despite the introduction of at least 20 new antiepileptic drugs (AEDs) into clinical practice
over the past decades, about one third of all epilepsies remain refractory to conventional …

Abstract That adenosine 5′ triphosphate (ATP) functions as an extracellular signaling
molecule has been established since the 1970s. Ubiquitous throughout the body as the …

Eighty years ago Drury & Szent-Gyorgyi described the actions of adenosine, AMP (adenylic
acid) and ATP (pyrophosphoric or diphosphoric ester of adenylic acid) on the mammalian …

There is a widespread presence of both adenosine (P1) and P2 nucleotide receptors in the
brain on both neurones and glial cells. Adenosine receptors play a major role in presynaptic …

Adenosine is a modulator of brain function uniquely positioned to integrate excitatory and
inhibitory neurotransmission. The past few years brought a wealth of new data fostering our …

Adenosine is a well-characterized endogenous anticonvulsant and seizure terminator of the
brain. Through a combination of adenosine receptor-dependent and-independent …

Adenosine is a potent anticonvulsant acting on excitatory synapses through A1 receptors.
Cellular release of ATP, and its subsequent extracellular enzymatic degradation to …

Epilepsy is one of the most serious and common chronic neurological conditions,
characterised by recurrent hypersynchronous electrical activity in the brain that lead to …

Purinergic signalling, ie ATP as an extracellular signalling molecule and cotransmitter in
both peripheral and central neurons, is involved in the physiology of neurotransmission and …