Autoimmune diseases, such as Systemic Lupus Erythematosus (SLE) or Rheumatoid
Arthritis (RA) are characterized by the breakdown of immunological tolerance. Defects of …

Regulatory T cells (Treg) are an important immune cell population, playing a crucial role in
regulating immune tolerance and preventing autoimmune diseases. These cells consist of …

Regulatory (Treg) cells are key regulators of inflammation and important for immune
tolerance and homeostasis. A major progress has been made in the identification and …

Naturally arising regulatory CD4+ T (Treg) cells, which specifically express the transcription
factor FoxP3 in the nucleus and CD25 and CTLA-4 on the cell surface, are a T-cell …

Since the characterization of CD4+ CD25+ regulatory T (Treg) cells in mice, significant
progress has been made in the definitions of the phenotype and the function of human Treg …

Regulatory T cells (Treg) play a dominant role in suppression of autoimmune pathology, as
rescue of Treg number and/or function in model systems can both prevent and reverse …

Cellular therapies using regulatory T (Treg) cells are currently undergoing clinical trials for
the treatment of autoimmune diseases, transplant rejection and graft-versus-host disease. In …

Naturally occurring CD4+ regulatory T cells (Tregs), which specifically express the
transcription factor FoxP3 in the nucleus and CD25 and CTLA-4 on the cell surface, are a …

Highlights•Foxp3+ Treg cells possess distinct transcriptional and epigenetic
landscapes.•Treg cell development is guided by gradual setup of an enhancer …

Self-tolerance, the state of unresponsiveness to self-tissues/antigens, is maintained through
central and peripheral tolerance mechanisms, and a breach of these mechanisms leads to …