At the root of the so-called precision medicine or precision oncology, which is our focus
here, is the hypothesis that cancer treatment would be considerably better if therapies were …

How can biophysical principles help precision medicine identify rare driver mutations? A
major tenet of pragmatic approaches to precision oncology and pharmacology is that driver …

The promise of precision medicine for cancer is already being realized with the recent
introduction of many targeted therapies, some with companion diagnostic tests that identify …

Current efforts in precision oncology largely focus on the benefit of genomics-guided
therapy. Yet, advances in sequencing techniques provide an unprecedented view of the …

Precision medicine trials and targeted therapies have shifted to the forefront of oncology.
Although targeted therapies have shown initial promise, implementation across the broad …

High-throughput DNA sequencing is revolutionizing the study of cancer and enabling the
measurement of the somatic mutations that drive cancer development. However, the …

Cancer is often driven by the accumulation of genetic alterations, including single nucleotide
variants, small insertions or deletions, gene fusions, copy-number variations, and large …

Despite the increased use of molecular diagnostics, the extent to which patients who have
these tests harbor potentially actionable aberrations is unclear. We retrospectively reviewed …

Our understanding of the molecular mechanisms underlying cancer development and
evolution have evolved rapidly over recent years, and the variation from one patient to …

The integration of machine learning and structure-based methods has proven valuable in
the past as a way to prioritize targets and compounds in early drug discovery. In oncological …