Tsc2 knockout counteracts ubiquitin-proteasome system insufficiency and delays photoreceptor loss in retinitis pigmentosa

Y Wang, C Punzo, JD Ash… - Proceedings of the …, 2022 - National Acad Sciences
Methods to stimulate protein degradation through the ubiquitin-proteasome system (UPS)
are being investigated as approaches to treat multiple human diseases and delay aging …

[HTML][HTML] TSC but not PTEN loss in starving cones of retinitis pigmentosa mice leads to an autophagy defect and mTORC1 dissociation from the lysosome

A Venkatesh, S Ma, C Punzo - Cell Death & Disease, 2016 - nature.com
Understanding the mechanisms that contribute to secondary cone photoreceptor loss in
retinitis pigmentosa (RP) is critical to devise strategies to prolong vision in this …

[HTML][HTML] MTOR-initiated metabolic switch and degeneration in the retinal pigment epithelium

YM Go, J Zhang, J Fernandes, C Litwin… - … : official publication of …, 2020 - ncbi.nlm.nih.gov
The retinal pigment epithelium (RPE) is a particularly vulnerable tissue to age-dependent
degeneration. Over the lifespan, the RPE develops an expanded endo-lysosomal …

[HTML][HTML] mTOR-mediated dedifferentiation of the retinal pigment epithelium initiates photoreceptor degeneration in mice

C Zhao, D Yasumura, X Li, M Matthes… - The Journal of …, 2011 - Am Soc Clin Investig
Retinal pigment epithelial (RPE) cell dysfunction plays a central role in various retinal
degenerative diseases, but knowledge is limited regarding the pathways responsible for …

[HTML][HTML] Activated mTORC1 promotes long-term cone survival in retinitis pigmentosa mice

A Venkatesh, S Ma, YZ Le, MN Hall… - The Journal of …, 2015 - Am Soc Clin Investig
Retinitis pigmentosa (RP) is an inherited photoreceptor degenerative disorder that results in
blindness. The disease is often caused by mutations in genes that are specific to rod …

Altered photoreceptor metabolism in mouse causes late stage age-related macular degeneration-like pathologies

SY Cheng, J Cipi, S Ma, BP Hafler… - Proceedings of the …, 2020 - National Acad Sciences
Age-related macular degeneration (AMD) is the leading cause of blindness in the elderly.
While the histopathology of the different disease stages is well characterized, the cause …

DARPP32, a target of hyperactive mTORC1 in the retinal pigment epithelium

J Cai, C Litwin, R Cheng, JX Ma… - Proceedings of the …, 2022 - National Acad Sciences
The mechanistic target of rapamycin (mTOR) is assembled into signaling complexes of
mTORC1 or mTORC2, and plays key roles in cell metabolism, stress response, and nutrient …

[HTML][HTML] mTOR pathway activation in age-related retinal disease

C Zhao, D Vollrath - Aging (Albany NY), 2011 - ncbi.nlm.nih.gov
Intriguingly, pharmacological inhibition of mTORC1 with rapamycin blunted RPE
dedifferentiation and hypertrophy and preserved photoreceptor numbers and function for …

[HTML][HTML] Abnormal mTORC1 signaling leads to retinal pigment epithelium degeneration

J Huang, S Gu, M Chen, S Zhang, Z Jiang, X Chen… - Theranostics, 2019 - ncbi.nlm.nih.gov
Retinal pigment epithelial (RPE) degeneration is potentially involved in the pathogenesis of
several retinal degenerative diseases. mTORC1 signaling is shown as a crucial regulator of …

[HTML][HTML] Subcellular distribution and activity of mechanistic target of rapamycin in aged retinal pigment epithelium

B Yu, P Xu, Z Zhao, J Cai… - … & visual science, 2014 - iovs.arvojournals.org
Purpose.: Inhibiting mechanistic target of rapamycin (mTOR) by pharmacological or genetic
approaches can extend lifespan in mammals. The kinase activity of mTOR is controlled by …