[HTML][HTML] Variability and heritability of mouse brain structure: Microscopic MRI atlases and connectomes for diverse strains
N Wang, RJ Anderson, DG Ashbrook… - Neuroimage, 2020 - Elsevier
Genome-wide association studies have demonstrated significant links between human brain
structure and common DNA variants. Similar studies with rodents have been challenging …
structure and common DNA variants. Similar studies with rodents have been challenging …
Whole mouse brain connectomics
G Allan Johnson, N Wang, RJ Anderson… - Journal of …, 2019 - Wiley Online Library
Methods have been developed to allow quantitative connectivity of the whole fixed mouse
brain by means of magnetic resonance imaging (MRI). We have translated what we have …
brain by means of magnetic resonance imaging (MRI). We have translated what we have …
Genetics of the connectome
Connectome genetics attempts to discover how genetic factors affect brain connectivity.
Here we review a variety of genetic analysis methods—such as genome-wide association …
Here we review a variety of genetic analysis methods—such as genome-wide association …
Mapping the regional influence of genetics on brain structure variability—a tensor-based morphometry study
CC Brun, N Leporé, X Pennec, AD Lee, M Barysheva… - Neuroimage, 2009 - Elsevier
Genetic and environmental factors influence brain structure and function profoundly. The
search for heritable anatomical features and their influencing genes would be accelerated …
search for heritable anatomical features and their influencing genes would be accelerated …
Structural covariance of brain region volumes is associated with both structural connectivity and transcriptomic similarity
An organizational pattern seen in the brain, termed structural covariance, is the statistical
association of pairs of brain regions in their anatomical properties. These associations …
association of pairs of brain regions in their anatomical properties. These associations …
Heritability of structural brain network topology: a DTI study of 156 twins
MM Bohlken, RCW Mandl, RM Brouwer… - Human brain …, 2014 - Wiley Online Library
Individual variation in structural brain network topology has been associated with heritable
behavioral phenotypes such as intelligence and schizophrenia, making it a candidate …
behavioral phenotypes such as intelligence and schizophrenia, making it a candidate …
Variability of brain anatomy for three common mouse strains
J Scholz, C LaLiberté, M van Eede, JP Lerch… - Neuroimage, 2016 - Elsevier
The way in which brain structures express different morphologies is not fully understood.
Here we investigate variability in brain anatomy using ex vivo MRI of three common …
Here we investigate variability in brain anatomy using ex vivo MRI of three common …
Genetic contributions to regional variability in human brain structure: methods and preliminary results
Twin studies provide one approach for investigating and partitioning genetic and
environmental contributions to phenotypic variability in human brain structure. Previous twin …
environmental contributions to phenotypic variability in human brain structure. Previous twin …
Human cortical thickness organized into genetically-determined communities across spatial resolutions
The cerebral cortex may be organized into anatomical genetic modules, communities of
brain regions with shared genetic influences via pleiotropy. Such modules could represent …
brain regions with shared genetic influences via pleiotropy. Such modules could represent …
[HTML][HTML] Where the genome meets the connectome: understanding how genes shape human brain connectivity
The integration of modern neuroimaging methods with genetically informative designs and
data can shed light on the molecular mechanisms underlying the structural and functional …
data can shed light on the molecular mechanisms underlying the structural and functional …