[HTML][HTML] Variability and heritability of mouse brain structure: Microscopic MRI atlases and connectomes for diverse strains

N Wang, RJ Anderson, DG Ashbrook… - Neuroimage, 2020 - Elsevier
Genome-wide association studies have demonstrated significant links between human brain
structure and common DNA variants. Similar studies with rodents have been challenging …

Whole mouse brain connectomics

G Allan Johnson, N Wang, RJ Anderson… - Journal of …, 2019 - Wiley Online Library
Methods have been developed to allow quantitative connectivity of the whole fixed mouse
brain by means of magnetic resonance imaging (MRI). We have translated what we have …

Genetics of the connectome

PM Thompson, T Ge, DC Glahn, N Jahanshad… - Neuroimage, 2013 - Elsevier
Connectome genetics attempts to discover how genetic factors affect brain connectivity.
Here we review a variety of genetic analysis methods—such as genome-wide association …

Mapping the regional influence of genetics on brain structure variability—a tensor-based morphometry study

CC Brun, N Leporé, X Pennec, AD Lee, M Barysheva… - Neuroimage, 2009 - Elsevier
Genetic and environmental factors influence brain structure and function profoundly. The
search for heritable anatomical features and their influencing genes would be accelerated …

Structural covariance of brain region volumes is associated with both structural connectivity and transcriptomic similarity

Y Yee, DJ Fernandes, L French, J Ellegood, LS Cahill… - Neuroimage, 2018 - Elsevier
An organizational pattern seen in the brain, termed structural covariance, is the statistical
association of pairs of brain regions in their anatomical properties. These associations …

Heritability of structural brain network topology: a DTI study of 156 twins

MM Bohlken, RCW Mandl, RM Brouwer… - Human brain …, 2014 - Wiley Online Library
Individual variation in structural brain network topology has been associated with heritable
behavioral phenotypes such as intelligence and schizophrenia, making it a candidate …

Variability of brain anatomy for three common mouse strains

J Scholz, C LaLiberté, M van Eede, JP Lerch… - Neuroimage, 2016 - Elsevier
The way in which brain structures express different morphologies is not fully understood.
Here we investigate variability in brain anatomy using ex vivo MRI of three common …

Genetic contributions to regional variability in human brain structure: methods and preliminary results

IC Wright, P Sham, RM Murray, DR Weinberger… - Neuroimage, 2002 - Elsevier
Twin studies provide one approach for investigating and partitioning genetic and
environmental contributions to phenotypic variability in human brain structure. Previous twin …

Human cortical thickness organized into genetically-determined communities across spatial resolutions

AF Alexander-Bloch, SR Mathias, PT Fox… - Cerebral …, 2019 - academic.oup.com
The cerebral cortex may be organized into anatomical genetic modules, communities of
brain regions with shared genetic influences via pleiotropy. Such modules could represent …

[HTML][HTML] Where the genome meets the connectome: understanding how genes shape human brain connectivity

A Arnatkeviciute, BD Fulcher, MA Bellgrove, A Fornito - Neuroimage, 2021 - Elsevier
The integration of modern neuroimaging methods with genetically informative designs and
data can shed light on the molecular mechanisms underlying the structural and functional …