[HTML][HTML] Effect of alpha-mangostin in the prevention of behavioural and neurochemical defects in methylmercury-induced neurotoxicity in experimental rats

R Sahu, S Mehan, S Kumar, A Prajapati, A Alshammari… - Toxicology reports, 2022 - Elsevier
Methylmercury (MeHg+) is a known neurotoxin that causes progressive motor neuron
degeneration in the central nervous system. Axonal degeneration, oligodendrocyte …

Protective effects of memantine against methylmercury-induced glutamate dyshomeostasis and oxidative stress in rat cerebral cortex

W Liu, Z Xu, Y Deng, B Xu, Y Wei, T Yang - Neurotoxicity research, 2013 - Springer
Methylmercury (MeHg) is one of the ubiquitous environmental toxicant that leads to long-
lasting neurological deficits in animals and humans. The identification of the underlying …

Protective effects of MK-801 on methylmercury-induced neuronal injury in rat cerebral cortex: involvement of oxidative stress and glutamate metabolism dysfunction

B Xu, ZF Xu, Y Deng, W Liu, HB Yang, YG Wei - Toxicology, 2012 - Elsevier
Methylmercury (MeHg) is one of the ubiquitous environmental toxicants, which can induce
oxidative stress and an indirect excitotoxicity caused by altered glutamate (Glu) metabolism …

Protective effects of apigenin on methylmercury-induced behavioral/neurochemical abnormalities and neurotoxicity in rats

RK Yadav, S Mehan, R Sahu, S Kumar… - Human & …, 2022 - journals.sagepub.com
Methylmercury (MeHg) is a neurotoxin that induces neurotoxicity and cell death in neurons.
MeHg increases oligodendrocyte death, glial cell activation, and motor neuron …

Memantine, a low-affinity NMDA receptor antagonist, protects against methylmercury-induced cytotoxicity of rat primary cultured cortical neurons, involvement of Ca 2+ …

W Liu, Z Xu, T Yang, B Xu, Y Deng, S Feng - Molecular Neurobiology, 2017 - Springer
Methylmercury (MeHg) is an extremely dangerous environmental pollutant that induces
severe toxic effects in the central nervous system. Neuronal damage plays critical roles …

Preventive effects of dextromethorphan on methylmercury-induced glutamate dyshomeostasis and oxidative damage in rat cerebral cortex

S Feng, Z Xu, W Liu, Y Li, Y Deng, B Xu - Biological trace element …, 2014 - Springer
Methylmercury (MeHg) is a well-known environmental pollutant leading to neurotoxicant
associated with aberrant central nervous system (CNS) functions, but its toxic mechanisms …

Attenuation of low dose methylmercury and glutamate induced‐cytotoxicity and tau phosphorylation by an N‐methyl‐D‐aspartate antagonist in human …

D Petroni, J Tsai, D Mondal… - Environmental …, 2013 - Wiley Online Library
Methylmercury (MeHg), a known neurotoxin, has been reported to alter glutamate
homeostasis in the neuronal environment resulting in excitotoxicity. This study was …

Mangiferin attenuates methylmercury induced cytotoxicity against IMR-32, human neuroblastoma cells by the inhibition of oxidative stress and free radical scavenging …

S Das, BN Rao, BSS Rao - Chemico-biological interactions, 2011 - Elsevier
Mangiferin (MGN), a C-glucosylxanthone was investigated for its ability to protect against
methylmercury (MeHg) induced neurotoxicity by employing IMR-32 (human neuroblastoma) …

Inhibition of Oxidative Neurotoxicity and Scopolamine‐Induced Memory Impairment by γ‐Mangostin: In Vitro and In Vivo Evidence

Y Lee, S Kim, Y Oh, YM Kim, YW Chin… - Oxidative medicine and …, 2019 - Wiley Online Library
Among a series of xanthones identified from mangosteen, the fruit of Garcinia mangostana
L.(Guttifereae), α‐and γ‐mangostins are known to be major constituents exhibiting diverse …

Neurotoxicity of methylmercury in isolated astrocytes and neurons: the cytoskeleton as a main target

P Pierozan, H Biasibetti, F Schmitz, H Ávila… - Molecular …, 2017 - Springer
In the present work, we focused on mechanisms of methylmercury (MeHg) toxicity in primary
astrocytes and neurons of rats. Cortical astrocytes and neurons exposed to 0.5–5 μM MeHg …