[HTML][HTML] Astrocytic Ca2+ signaling is reduced during sleep and is involved in the regulation of slow wave sleep
Astrocytic Ca2+ signaling has been intensively studied in health and disease but has not
been quantified during natural sleep. Here, we employ an activity-based algorithm to assess …
been quantified during natural sleep. Here, we employ an activity-based algorithm to assess …
[HTML][HTML] Distinct astrocytic modulatory roles in sensory transmission during sleep, wakefulness, and arousal states in freely moving mice
Despite extensive research on astrocytic Ca2+ in synaptic transmission, its contribution to
the modulation of sensory transmission during different brain states remains largely …
the modulation of sensory transmission during different brain states remains largely …
[PDF][PDF] A role for astroglial calcium in mammalian sleep and sleep regulation
AM Ingiosi, CR Hayworth, DO Harvey, KG Singletary… - Current Biology, 2020 - cell.com
Mammalian sleep expression and regulation have historically been thought to reflect the
activity of neurons. Changes in other brain cells (glia) across the sleep-wake cycle and their …
activity of neurons. Changes in other brain cells (glia) across the sleep-wake cycle and their …
[PDF][PDF] Astroglial calcium signaling encodes sleep need in Drosophila
Sleep is under homeostatic control, whereby increasing wakefulness generates sleep need
and triggers sleep drive. However, the molecular and cellular pathways by which sleep need …
and triggers sleep drive. However, the molecular and cellular pathways by which sleep need …
[HTML][HTML] Adenosine-independent regulation of the sleep–wake cycle by astrocyte activity
Astrocytes play a crucial role in regulating sleep–wake behavior, and adenosine signaling is
generally thought to be involved. Here we show multiple lines of evidence supporting that …
generally thought to be involved. Here we show multiple lines of evidence supporting that …
A role for the cortex in sleep–wake regulation
Cortical and subcortical circuitry are thought to play distinct roles in the generation of sleep
oscillations and global state control, respectively. Here we silenced a subset of neocortical …
oscillations and global state control, respectively. Here we silenced a subset of neocortical …
[PDF][PDF] Involvement of Ca2+-dependent hyperpolarization in sleep duration in mammals
The detailed molecular mechanisms underlying the regulation of sleep duration in mammals
are still elusive. To address this challenge, we constructed a simple computational model …
are still elusive. To address this challenge, we constructed a simple computational model …
Cell-type-specific dynamics of calcium activity in cortical circuits over the course of slow-wave sleep and rapid eye movement sleep
Sleep shapes cortical network activity, fostering global homeostatic downregulation of
excitability while maintaining or even upregulating excitability in selected networks in a …
excitability while maintaining or even upregulating excitability in selected networks in a …
Neuro-orchestration of sleep and wakefulness
Although considered an inactive state for centuries, sleep entails many active processes
occurring at the cellular, circuit and organismal levels. Over the last decade, several key …
occurring at the cellular, circuit and organismal levels. Over the last decade, several key …
Impaired astrocytic Ca2+ signaling in awake-behaving Alzheimer's disease transgenic mice
KS Åbjørsbråten, GHES Skaaraas, C Cunen… - Elife, 2022 - elifesciences.org
Increased astrocytic Ca2+ signaling has been shown in Alzheimer's disease mouse models,
but to date no reports have characterized behaviorally induced astrocytic Ca2+ signaling in …
but to date no reports have characterized behaviorally induced astrocytic Ca2+ signaling in …