Psychiatric disorders, including major depressive disorder (MDD), bipolar disorder (BD) and
schizophrenia, affect a significant percentage of the world population. These disorders are …

Mental disorders (MDs) are highly prevalent and potentially debilitating complex disorders
which causes remain elusive. Looking into deeper aspects of etiology or pathophysiology …

Psychological stress promotes the development and recurrence of anxiety and depressive
behavioral symptoms. Basic and clinical research indicates that stress exposure can …

Persistent cognitive and behavioral symptoms that characterize many mental health
disorders arise from impaired neuroplasticity in several key corticolimbic brain regions …

Increasing evidence supports the notion that neuroinflammation plays a critical role in the
etiology of major depressive disorder (MDD), at least in a subset of patients. By virtue of their …

Neuropsychiatric disorders (ie, mood disorders and schizophrenia) and inflammation are
closely intertwined, and possibly powering each other in a bidirectional loop. Depression …

Rationale Psychosocial stressors are a well-documented risk factor for mental illness.
Neuroinflammation, in particular elevated microglial activity, has been proposed to mediate …

Brain diseases and disorders such as Alzheimer disease, Parkinson disease, depression,
schizophrenia, autism, and addiction lead to reduced quality of daily life through abnormal …

Stress due to adverse and demanding conditions alters immune functions. How innate and
adaptive immune systems respond to stress and affect neural processes remains unclear …

Schizophrenia is a disorder with a heterogeneous etiology involving complex interplay
between genetic and environmental risk factors. The immune system is now known to play …