The APOE4 variant of apolipoprotein E (apoE) is the most prevalent genetic risk allele
associated with late‐onset Alzheimer's disease (AD). ApoE interacts with complement …

The APOE4 allele of apolipoprotein E (apoE) is the greatest genetic risk factor for
Alzheimer's disease (AD) compared to APOE2 and APOE3. Amyloid-β (Aβ), particularly in a …

Among the three human apolipoprotein E (apoE) isoforms, apoE4 increases the risk of
Alzheimer's disease (AD). While transporting cholesterol is a primary function, apoE also …

Alzheimer's disease (AD) is the most prevalent form of neurodegenerative disease, currently
affecting over 5 million Americans with projections expected to rise as the population ages …

Apolipoprotein E4 (ApoE4) increases the risk of late-onset Alzheimer's disease (AD). It binds
tightly to β-amyloid protein (A β), which is known to activate the classical complement …

The APOE genotype is the most prominent genetic risk factor for the development of late-
onset Alzheimer''s disease (LOAD); however, the underlying mechanisms remain unclear. In …

Apolipoprotein E (ApoE) is a secreted apolipoprotein with three isoforms, E2, E3, and E4,
that binds to lipids and facilitates their transport in the extracellular environment of the brain …

Apolipoprotein E4 (apoE4) is the major genetic risk factor for Alzheimer's disease (AD) by an
as yet to be defined mechanism. Since the structure or biophysical properties of a protein …

Background Having the apolipoprotein E4 (APOE-ϵ4) allele is the strongest genetic risk
factor for the development of Alzheimer's disease (AD). Accumulation of amyloid beta (Aβ) in …

The strongest genetic risk factor influencing susceptibility to late-onset Alzheimer's disease
(AD) is apolipoprotein E (APOE) genotype. APOE has three common isoforms in humans …