Neural stem cells improve memory in an inducible mouse model of neuronal loss

TR Yamasaki, M Blurton-Jones… - Journal of …, 2007 - Soc Neuroscience
Neuronal loss is a major pathological outcome of many common neurological disorders,
including ischemia, traumatic brain injury, and Alzheimer disease. Stem cell-based …

[HTML][HTML] Stem cell therapy in brain trauma: implications for repair and regeneration of injured brain in experimental TBI models

A Rolfe, D Sun - 2015 - europepmc.org
Traumatic brain injury (TBI) is a major health problem worldwide. Currently, there is no
effective treatment to improve neural structural repair and functional recovery of patients in …

Stem cell therapy for human neurodegenerative disorders–how to make it work

O Lindvall, Z Kokaia, A Martinez-Serrano - Nature medicine, 2004 - nature.com
Recent progress shows that neurons suitable for transplantation can be generated from
stem cells in culture, and that the adult brain produces new neurons from its own stem cells …

Potentials of endogenous neural stem cells in cortical repair

B Saha, M Jaber, A Gaillard - Frontiers in cellular neuroscience, 2012 - frontiersin.org
In the last few decades great thrust has been put in the area of regenerative neurobiology
research to combat brain injuries and neurodegenerative diseases. The recent discovery of …

Neuroreplacement therapy and stem cell biology under disease conditions

K Sugaya - Cellular and Molecular Life Sciences CMLS, 2003 - Springer
Recent advances in stem cell technology are expanding our ability to replace a variety of
cells throughout the body. In the past, neurological diseases caused by the degeneration of …

Stem cells in neuroinjury and neurodegenerative disorders: challenges and future neurotherapeutic prospects

TH Mouhieddine, FH Kobeissy, M Itani… - Neural regeneration …, 2014 - journals.lww.com
The prevalence of neurodegenerative diseases and neural injury disorders is increasing
worldwide. Research is now focusing on improving current neurogenesis techniques …

Stem cells for ischemic brain injury: a critical review

TC Burns, CM Verfaillie, WC Low - Journal of Comparative …, 2009 - Wiley Online Library
No effective therapy is currently available to promote recovery following ischemic stroke.
Stem cells have been proposed as a potential source of new cells to replace those lost due …

Human neural stem cells reinforce hippocampal synaptic network and rescue cognitive deficits in a mouse model of Alzheimer's disease

T Zhang, W Ke, X Zhou, Y Qian, S Feng, R Wang, G Cui… - Stem cell reports, 2019 - cell.com
Alzheimer's disease (AD) is characterized by memory impairments in its earliest clinical
phase. The synaptic loss and dysfunction leading to failures of synaptic networks in AD brain …

Regeneration of the ischemic brain by engineered stem cells: fuelling endogenous repair processes

CTJ van Velthoven, A Kavelaars, F van Bel… - Brain research …, 2009 - Elsevier
After ischemic brain injury various cell types including neurons, glia and endothelial cells
are damaged and lose their function. Effective regeneration of brain tissue requires that all …

Stem cells and neurological diseases

DC Hess, CV Borlongan - Cell proliferation, 2008 - Wiley Online Library
Cells of the central nervous system were once thought to be incapable of regeneration. This
dogma has been challenged in the last decade with studies showing new, migrating stem …