Apoptosis is crucial for the normal development of the nervous system, whereas neurons in
the adult CNS are relatively resistant to this form of cell death. However, under pathological …

Neuroinflammation is a complex inflammatory process in the nervous system that is
expected to play a significant role in neurological diseases. Necroptosis is a kind of necrosis …

Multiple sclerosis (MS), a common neurodegenerative disease of the CNS, is characterized
by the loss of oligodendrocytes and demyelination. Tumor necrosis factor α (TNF-α), a …

Programmed cell death has a vital role in embryonic development and tissue homeostasis.
Necroptosis is an alternative mode of regulated cell death mimicking features of apoptosis …

Neurodegenerative diseases are a group of chronic progressive disorders characterized by
neuronal loss. Necroptosis, a recently discovered form of programmed cell death, is a cell …

Necroptosis is a form of regulated necrosis controlled by receptor-interacting kinase 1
(RIPK1 or RIP1), RIPK3 (RIP3), and pseudokinase mixed lineage kinase domain-like protein …

A process of regulated necrosis, termed necroptosis, has been recognized as a major
contributor to cell death and inflammation occurring under a wide range of pathologic …

In the early 2000s, receptor-interacting serine/threonine protein kinase 1 (RIPK1), a
molecule already recognized as an important regulator of cell survival, inflammation and …

Necroptosis is a form of regulated cell death, which is induced by ligand binding to TNF
family death domain receptors, pattern recognizing receptors and virus sensors. The …

Necroptosis is a genetically regulated form of necrotic cell death that has emerged as an
important pathway in human disease. The necroptosis pathway is induced by a variety of …