Interleukin-23 (IL-23) is a pro-inflammatory cytokine composed of two subunits, IL-23A (p19)
and IL-12/23B (p40), the latter shared with Interleukin-12 (IL-12). IL-23 is mainly produced …

The discovery that the IL-23–IL-17 immune pathway is involved in many models of
autoimmune disease has changed the concept of the role of T-helper cell subsets in the …

Over the past few years, the importance of Interleukin (IL)-17 and T helper (Th) 17 cells in
the pathology of Rheumatoid Arthritis (RA) has become apparent. RA is a systemic …

IL-17 (interleukin-17), a hallmark cytokine of Th17 (T-helper 17) cells, plays critical roles in
host defence against bacterial and fungal infections, as well as in the pathogenesis of …

The IL-12 family members, IL-12, IL-23, IL-27 and IL-35, are heterodimeric cytokines that
share subunits and have important roles in autoimmunity. As well as their structural …

Increasing evidence has revealed the importance of IL-23, which closely resembles IL-12
both structurally and immunologically, in linking innate and adaptive immunity. IL-23 …

Abstract Interleukin-23 (IL-23) is a pro-inflammatory cytokine composed of two subunits, p19
and p40. The p40 subunit is shared with IL-12. IL-23 and IL-12 have different receptors and …

Systemic rheumatic diseases are a heterogeneous group of autoimmune disorders that
affect the connective tissue, characterized by the involvement of multiple organs, leading to …

Interleukin (IL)-23 is a heterodimeric cytokine closely related to IL-12. Yet, despite a strong
structural relationship that includes a shared p40 subunit, this does not translate into …

Summary Interleukin‐23 (IL‐23) is a member of the IL‐12 family of cytokines with pro‐
inflammatory properties. Its ability to potently enhance the expansion of T helper type 17 …