Chronic kidney disease (CKD) and acute kidney injury (AKI) are public health problems, and
their prevalence rates have increased with the aging of the population. They are associated …

Renal fibrosis is an irreversible and progressive process that causes severe dysfunction in
chronic kidney disease (CKD). The progression of CKD stages is highly associated with a …

Background Studies have shown that the Klotho gene has tremendous potential for future
therapeutic purposes in both acute and chronic kidney diseases (CKD). This study aimed to …

Through alternative splicing, Klotho protein exists both as a secreted and a membrane form
whose extracellular domain could be shed from the cell surface by secretases and released …

Klotho is a novel renoprotective anti-aging protein available in membrane-bound or soluble
form. Klotho is expressed in brain, pancreas, and other solid organs but shows highest …

Chronic kidney disease (CKD) is an inherently systemic disease that refers to a long-term
loss of kidney function. The progression of CKD has repercussions for other organs, leading …

Klotho is a protein primarily expressed in renal tubular epithelial cells. Studies have
suggested that Klotho is an antiaging protein that reduces renal fibrosis after acute kidney …

Klotho is highly expressed in the kidney and a soluble form of Klotho functions as an
endocrine substance that exerts multiple actions including the modulation of renal solute …

Klotho is a single-pass transmembrane protein that is highly expressed in the kidney and is
known to act as a coreceptor for fibroblast growth factor 23. The extracellular domain can be …

The Klotho protein, known as an antiaging protein, is expressed mainly in the kidney, and
kidney disorders may contribute to the disrupted expression of renal Klotho. The purpose of …