Fc receptors (FcRs) belong to the ITAM-associated receptor family. FcRs control the humoral
and innate immunity which are essential for appropriate responses to infections and …

Inhibitory signaling is an emerging function of ITAM-bearing immunoreceptors in the
maintenance of homeostasis. Monovalent targeting of the IgA Fc receptor (FcαRI or CD89) …

Serum IgA is considered a discrete housekeeper of the immune system with multiple anti-
inflammatory functions, whereas IgA-immune complexes mediate inflammatory responses …

Most Ig receptors exist as multi-subunit complexes with a unique ligand binding alpha chain
and a common signaling FcR gamma-chain. The myeloid Fc gamma RIIa (CD32) appears …

Introduction: The Fc receptors (FcRs) and their interactions with immunoglobulin and innate
immune opsonins, such as C-reactive protein, are key players in humoral and cellular …

Rheumatoid arthritis–associated (RA-associated) inflammation is mediated through the
interaction between RA IgG immune complexes and IgG Fc receptors on immune cells …

Intravenous immunoglobulin (IVIg) has been used in the treatment of several autoimmune
and inflammatory diseases. However, its mechanism of action remains incompletely …

The cell-triggering properties of BCR, TCR and FcR depend on structurally related
immunoreceptor tyrosine-based activation motifs (ITAMs). FcyRllB have no ITAM and do not …

Receptors for immunoglobulin Fc regions play multiple critical roles in the immune system,
mediating functions as diverse as phagocytosis, triggering degranulation of basophils and …

Immune homeostasis is regulated by a finely tuned network of positive–negative regulatory
mechanisms that guarantees proper surveillance avoiding hyperactivity that would lead to …