Understanding Fc receptor involvement in inflammatory diseases: from mechanisms to new therapeutic tools
S Ben Mkaddem, M Benhamou… - Frontiers in …, 2019 - frontiersin.org
Fc receptors (FcRs) belong to the ITAM-associated receptor family. FcRs control the humoral
and innate immunity which are essential for appropriate responses to infections and …
and innate immunity which are essential for appropriate responses to infections and …
Inhibitory ITAM signaling by FcαRI-FcRγ chain controls multiple activating responses and prevents renal inflammation
Y Kanamaru, S Pfirsch, M Aloulou… - The Journal of …, 2008 - journals.aai.org
Inhibitory signaling is an emerging function of ITAM-bearing immunoreceptors in the
maintenance of homeostasis. Monovalent targeting of the IgA Fc receptor (FcαRI or CD89) …
maintenance of homeostasis. Monovalent targeting of the IgA Fc receptor (FcαRI or CD89) …
Identification of FcαRI as an inhibitory receptor that controls inflammation: dual role of FcRγ ITAM
B Pasquier, P Launay, Y Kanamaru, IC Moura… - Immunity, 2005 - cell.com
Serum IgA is considered a discrete housekeeper of the immune system with multiple anti-
inflammatory functions, whereas IgA-immune complexes mediate inflammatory responses …
inflammatory functions, whereas IgA-immune complexes mediate inflammatory responses …
Functional differences between two Fc receptor ITAM signaling motifs
IE Van den Herik-Oudijk, MW Ter Bekke… - 1995 - ashpublications.org
Most Ig receptors exist as multi-subunit complexes with a unique ligand binding alpha chain
and a common signaling FcR gamma-chain. The myeloid Fc gamma RIIa (CD32) appears …
and a common signaling FcR gamma-chain. The myeloid Fc gamma RIIa (CD32) appears …
Targeting the Fc receptor in autoimmune disease
X Li, RP Kimberly - Expert opinion on therapeutic targets, 2014 - Taylor & Francis
Introduction: The Fc receptors (FcRs) and their interactions with immunoglobulin and innate
immune opsonins, such as C-reactive protein, are key players in humoral and cellular …
immune opsonins, such as C-reactive protein, are key players in humoral and cellular …
Shifting FcγRIIA-ITAM from activation to inhibitory configuration ameliorates arthritis
SB Mkaddem, G Hayem, F Jönsson… - The Journal of …, 2014 - Am Soc Clin Investig
Rheumatoid arthritis–associated (RA-associated) inflammation is mediated through the
interaction between RA IgG immune complexes and IgG Fc receptors on immune cells …
interaction between RA IgG immune complexes and IgG Fc receptors on immune cells …
IgG1 and IVIg induce inhibitory ITAM signaling through FcγRIII controlling inflammatory responses
M Aloulou, S Ben Mkaddem… - Blood, The Journal …, 2012 - ashpublications.org
Intravenous immunoglobulin (IVIg) has been used in the treatment of several autoimmune
and inflammatory diseases. However, its mechanism of action remains incompletely …
and inflammatory diseases. However, its mechanism of action remains incompletely …
The same tyrosine-based inhibition motif, in the intra-cytoplasmic domain of FcγRIIB, regulates negatively BCR-, TCR-, and FcR-dependent cell activation
The cell-triggering properties of BCR, TCR and FcR depend on structurally related
immunoreceptor tyrosine-based activation motifs (ITAMs). FcyRllB have no ITAM and do not …
immunoreceptor tyrosine-based activation motifs (ITAMs). FcyRllB have no ITAM and do not …
Of ITIM s, ITAM s, and ITAM is: revisiting immunoglobulin Fc receptor signaling
A Getahun, JC Cambier - Immunological reviews, 2015 - Wiley Online Library
Receptors for immunoglobulin Fc regions play multiple critical roles in the immune system,
mediating functions as diverse as phagocytosis, triggering degranulation of basophils and …
mediating functions as diverse as phagocytosis, triggering degranulation of basophils and …
Inhibitory ITAMs as novel regulators of immunity
U Blank, P Launay, M Benhamou… - Immunological …, 2009 - Wiley Online Library
Immune homeostasis is regulated by a finely tuned network of positive–negative regulatory
mechanisms that guarantees proper surveillance avoiding hyperactivity that would lead to …
mechanisms that guarantees proper surveillance avoiding hyperactivity that would lead to …