ABSTRACT Messenger RNA (mRNA) 3′ end formation is a nuclear process through which
all eukaryotic primary transcripts are endonucleolytically cleaved and most of them acquire a …

Formation of the 3′ end of a eukaryotic mRNA is a key step in the production of a mature
transcript. This process is mediated by a number of protein factors that cleave the pre …

Recent advances in the understanding of the molecular mechanism of mRNA 3′ end
processing have uncovered a previously unanticipated integrated network of transcriptional …

Recent advances in understanding the molecular mechanism of mRNA 3′ end cleavage
and polyadenylation have uncovered an unanticipated involvement of this process in the …

The majority of eukaryotic messenger RNA precursors (pre-mRNAs) undergo cleavage and
polyadenylation at their 3′ end. This canonical 3′-end processing depends on sequence …

The 3′‐ends of almost all eukaryotic mRNAs are formed in a two‐step process, an
endonucleolytic cleavage followed by polyadenylation (the addition of a poly‐adenosine or …

Pre‐mRNA cleavage and polyadenylation is an essential step for 3′ end formation of
almost all protein‐coding transcripts in eukaryotes. The reaction, involving cleavage of …

In principle, the formation of the 3 end of a eukaryotic mRNA is a simple process. At a
minimum, it involves the hydrolysis of a single phosphodiester bond in the nascent …

A poly (A) tail is found at the 3 end of nearly every fully processed eukaryotic mRNA and has
been suggested to influence virtually all aspects of mRNA metabolism. Its proposed …

Pre-mRNA 3′ end formation is an essential step in eukaryotic gene expression. Over half of
human genes produce alternatively polyadenylated mRNAs, suggesting that regulated …