Ischemic stroke is one of the significant causes of morbidity and mortality, affecting millions
of people across the globe. Cell injury in the infarct region is an inevitable consequence of …

As a result of ischemia or hemorrhage, blood supply to neurons is disrupted which
subsequently promotes a cascade of pathophysiological responses resulting in cell loss …

Ischemic stroke caused by arterial occlusion is the most common type of stroke, which is
among the most frequent causes of disability and death worldwide. Current treatment …

Focal permanent or transient cerebral artery occlusion produces massive cell death in the
central core of the infarction, whereas in the peripheral zone (penumbra) nerve cells are …

Background and Purpose—Traditionally, cell death after cerebral ischemia was considered
to be exclusively necrotic in nature, but research over the past decade has revealed that …

Ischemic stroke caused by intracranial vascular occlusion has become increasingly
prevalent with considerable mortality and disability, which gravely burdens the global …

It has been a major challenge to develop effective therapeutics for stroke, a leading cause of
death and serious debilitation. Intensive research in the past 15 years have implicated many …

Acute ischemic stroke is inadequately treated in the USA and worldwide due to a lengthy
history of neuroprotective drug failures in clinical trials. The majority of victims must endure …

Apoptosis may contribute to a significant proportion of neuron death following acute brain
ischemia (ABI), but the underlying mechanisms are still not fully understood. Brain ischemia …

Programmed cell death (PCD) is an ordered and tightly controlled set of changes in gene
expression and protein activity that results in neuronal cell death during brain development …