Fibroblasts are critical pro-inflammatory regulators in chronic inflammatory and fibrotic skin
diseases. However, fibroblast heterogeneity and the absence of a unified cross-disease …

Fibroblasts are crucial components of the skin structure. They were traditionally believed to
maintain the skin's structure by producing extracellular matrix and other elements. Recent …

Tissue fibrosis is the deposition of excessive extracellular matrix and can occur as part of the
body's natural wound healing process upon injury, or as a consequence of diseases such as …

Background Pro-inflammatory fibroblasts are critical for pathogenesis in rheumatoid arthritis,
inflammatory bowel disease, interstitial lung disease, and Sjögren's syndrome and represent …

The skin is exposed to environmental challenges and contains heterogeneous cell
populations such as epithelial cells, stromal cells, and skin-resident immune cells. As the …

Background/Objective: Skin fibrosis is the result of aberrant processes leading to abnormal
deposition of extracellular matrix (ECM) in the dermis. In healthy skin, keratinocytes …

Abstract Purpose of Review Fibroblasts, the major cell population in all connective tissues,
are best known for their role in depositing and maintaining the extracellular matrix. Recently …

The skin is the outermost barrier of the body. It has developed a sophisticated system
against the ever-changing environment. The application of single-cell technologies has …

Objective In this study, we sought a comprehensive understanding of myeloid cell types
driving fibrosis in diffuse cutaneous systemic sclerosis (dcSSc) skin. Methods We analyzed …

Fibroblasts are the main cell type in the dermis. They are responsible for the synthesis and
deposition of structural proteins such as collagen and elastin, which are integrated into the …