Bioluminescence and fluorescence resonance energy transfer (BRET and FRET) together
with the proximity ligation method revealed the existence of G-protein-coupled receptors …

Dysfunction of adenosine heteroreceptor complexes can contribute to mental disorder
development (Borroto-Escuela et al., 2018a; Beggiato et al., 2021; Merighi et al., 2021) …

Until recently, heptahelical G-protein-coupled receptors (GPCRs) were considered to be
expressed as monomers on the cell surface of neuronal and non-neuronal cells. It is now …

By analyzing the functional role of adenosine receptor heteromers, we review a series of
new concepts that should modify our classical views of neurotransmission in the central …

While the G protein-coupled receptor (GPCR) oligomerization has been questioned during
the last fifteen years, the existence of a multi-receptor complex involving direct receptor …

G protein-coupled receptors (GPCRs) are targets for therapy in a variety of neurological
diseases. Using adenosine A 1 receptors (A 1 Rs) as paradigm of GPCRs, this review …

The 'omnipresence'of adenosine in all nervous system cells (neurons and glia) together with
the intensive release of adenosine following insults, makes adenosine as a sort of …

The discovery that receptors from all families can establish allosteric receptor–receptor
interactions and variably associate to form receptor complexes operating as integrative input …

G-protein coupled receptors are transmembrane proteins widely expressed in cells and their
transduction pathways are mediated by controlling second messenger levels through …

G protein-coupled receptors (GPCRs) constitute the largest superfamily of membrane
proteins in higher eukaryotes, and facilitate information transfer from the extracellular …